Representative Publications

ALZHEIMER'S DISEASE
AMINO ACIDS
CHOLINE/ACETYLCHOLINE/PHOSPHATIDES/FATTY ACIDS
CLINICAL
DOPA/DOPAMINE/NOREPINEPHRINE/EPINEPHRINE
ENDOCRINOLOGY
FEEDING & OBESITY
LIGHT
MEDICAL HISTORY
MELATONIN
SEROTONIN

Full Publications List (pdf)

Alzheimer's Disease
Wurtman, R.J. Alzheimer's disease. Sci. Am., 252:62-74, 1985.
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Nitsch, R.M., Blusztajn, J.K., Pittas, A.G., Slack, B.E., Growdon, J.H., Wurtman, R.J. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci., 89:1671-1675, 1992.
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Nitsch, R.M., Slack, B.E., Wurtman, R.J., Growdon, J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science, 258:304-307, 1992.
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Hung, A.Y., Haass, C., Nitsch, R.M., Qiu, W.Q., Citron, M., Wurtman, R.J., Growdon, J.H., and Selkoe, D.J. Activation of protein kinase C inhibits cellular production of the amyloid ß-protein. J. Biol. Chem., 268(31):22959-22962, 1993.
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Nitsch, R.M., Farber, S.A., Growdon, J.H., and Wurtman, R.J. Release of amyloid ß-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc. Natl. Acad. Sci., 90:5191-5193, 1993.
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Nitsch, R.M., Wurtman, R.J., Growdon, J.H. Regulation of proteolytic processing of the amyloid ß-protein precursor by first messengers: A novel approach for the treatment of Alzheimer's disease. Drug Res., 45(1)435-438, 1995.
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Lee, R.K.K., Wurtman, R.J., Cox, A.J., and Nitsch, R.M. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc. Natl. Acad. Sci., 92:8083-8087, 1995.
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Farber, S.A., Nitsch, R.M., Schultz, J.G., and Wurtman, R.J. Regulated secretion of ß-amyloid precursor protein in rat brain. J. Neurosci., 15(11):7442-7451, 1995.
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Nitsch, R.M., Deng, M., Growdon, J.H., and Wurtman, R.J. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. J. Biol. Chem., 271(8):4188-4194, 1996.
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Petryniak, M.A., Wurtman, R.J., and Slack, B.E. Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism. Biochem. J., 320:957-963, 1996.
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Ulus, I.H., and Wurtman, R.J. Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices. J. Pharm. Exp. Ther., 281:149-154, 1997.
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Lee, R.K.K., and Wurtman, R.J. Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: Inhibition by cyclic AMP. J. Neurochem., 68(5):1830-1835, 1997.
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Lee, R.K.K., Araki, W., and Wurtman, R.J. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proc. Natl. Acad. Sci., 94:5422-5426, 1997.
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Nitsch, R.M., Deng, A., Wurtman, R.J., and Growdon, J.H. Metabotropic glutamate receptor subtype mGluR1a stimulates the secretion of the amyloid ß-protein precursor ectodomain. J. Neurochem., 69(2):704-712, 1997.
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Slack, B.E., Breu, J., Muchnicki, L., and Wurtman, R.J. Rapid stimulation of amyloid precursor protein release by epidermal growth factor: Role of protein kinase C. Biochem. J., 327:245-249, 1997.
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Lee, R.K.K., Knapp, S., and Wurtman, R.J. Prostaglandin E2 stimulates amyloid precursor protein gene expression: Inhibition by immunosuppressants. J. Neurosci., 19(3):940-947, 1999.
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Wang, C., Wurtman, R.J., and Lee, R.K.K. Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Aß1-40. Brain Res., 865:157-167, 2000.
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Arjona, A.A., Pooler, A.M., Wurtman, R.J., and Lee, R.K. Effect of 5-HT2C serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in Guinea pigs. Brain Research, 951:135-140, 2002.
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Teather, L.A., Magnusson, J.E., Chow, C.M., and Wurtman, R.J. Environmental conditions influence hippocampal-dependent behaviors and brain levels of amyloid precursor protein. Eur. J. Neurosci. 16:2405-2415,2002.
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Pooler, A.M., Arjona, A.A., Lee, R.K., and Wurtman, R.J. Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia. Neurosci. Letters 362:127-130, 2004.
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Teather, L.A. and Wurtman, R.J. Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats. Learning and Memory 12:39-43, 2005.
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Teather, L.A. and Wurtman, R.J. Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats. Progress in Neuro-Psychopharm. & Biological Psychiatry 27:711-717, 2003.
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Pooler, A.M., Xi, S.C., Wurtman, R.J. The 3-hydrox-3-methyglutary co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. J. Neurochem. 97:716-723, 2006.
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Slack, B.E., Wurtman, R.J. Regulation of synthesis and metabolism of the amyloid precursor protein by extracellular signals. Research Progress in Alzheimer's Disease and Dementia ed. Miao-Kun Sun,Chpt. 1, pp. 1-29, 2006.[PDF]
Cansev, M., Wurtman R.J., Sakamoto, T., Ulus, I.H. Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Alzheimer's & Dementia 4:S153-S168, 2008. [PDF]
Cansev, M., Ulus, I.H., Wang, L., Maher T.J., Wurtman, R.J. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. Neuroscience Research62L106-209 2008. [PDF]
Cansev, M., Marzloff, G., Sakamoto, T., Ulus, I.H., Wurtman, R.J. Giving uridine plus docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Developmental Neuroscience, submitted, 2008. [PDF]
Wurtman, R.J., Cansev, M., Ulus, I.H. Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides. The Journal of Nutrition, Health & Aging Vol. , in press, 2009. [PDF]
Wurtman, R. Synapse formation and cognitive brain development: effect of docosahezxaenoic acid and other dietary constituents. Metabolism 57(2):S6-S10, 2008. [PDF]
Wurtman, R.J., Cansev, M., Sakamoto, T., Ulus, I.H. Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. Omega-3 Fatty Acids, the Brain and Retina. In: World Review of Nutrition and Dietetics (A.P. Simopoulos, N.G. Gazan, eds.), Karger, Basel, Vol. 99, pp. S153-S168, 2008. [PDF]
Wurtman, R.J. Use of phosphatide precursors to promote synaptogenesis. Annual Reviews of Nutrition Vol. 29 (in press), 2008. [PDF]
Kamphuis, P.J., Wurtman, R.J. Nutrition and AlZheimer's disease: pre-clinical concepts. European Journal of Neurology 16(Suppl 1):12-18. [PDF]
Scheltens, P., Kamphuis, P.J.G.H., Verhey, F.R.J., olde Rikkert, M.G.M., Wurtman, R.J., Wilkinson, D., Twisk J.W.R., Kurz, A. Efficacy of a medical food in mild Alzheimer's disease: a randomized controlled trial. Alzheimer's and Dementia, in press, 2009. [PDF]
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Amino Acids
Wurtman, R.J., and Axelrod, J. Daily rhythmic changes in the tyrosine transaminase of the rat liver. Proc. Nat. Acad. Sci., 57(6):1594-1598, 1967.
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Wurtman, R.J., Chou, C., and Rose, C.M. Daily rhythm in tyrosine concentration in human plasma: Persistence on low-protein diets. Science, 158(3801):660-662, 1967.
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Wurtman, R.J., and Larin, R. A sensitive and specific isotopic assay for the estimation of tyrosine transaminase. Biochem. Pharm., 17:817-818, 1968.
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Wurtman, R.J., Shoemaker, W.J., and Larin, F. Mechanism of the daily rhythm in hepatic tyrosine transaminase activity: Role of dietary tryptophan. Proc. Nat. Acad. Sci., 59(3):800-807, 1968.
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Wurtman, R.J., Rose, C.M., Chou, C., and Larin, F.F. Daily rhythms in the concentrations of various amino acids in human plasma. New Eng. J. Med., 279(4):171-175, 1968.
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Zigmond, M.J., Shoemaker, W.J., Larin, F., and Wurtman, R.J. Hepatic tyrosine transaminase rhythm: Interaction of environmental lighting, food consumption and dietary protein content. J. Nutrition, 98(1):71-75, 1969.
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Fishman, B, Wurtman, R.J., and Munro, H.N. Daily rhythms in hepatic polysome profiles and tyrosine transaminase activity: Role of dietary protein. Proc. Nat. Acad. Sci., 64(2):677-682, 1969.
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Wurtman, R.J. Diurnal rhythms in mammalian protein metabolism. In: Mammalian Protein Metabolism (H.N. Munro, ed.) Academic Press, New York, Vol 4, Chapter 36, 1970.[PDF]
Cohn, C., Joseph, D., Larin, F., Shoemaker, W.J., Wurtman, R.J. Influence of feeding habits and adrenal cortex on diurnal rhythm of hepatic tyrosine transaminase activity. Proc. Soc. Exp. Biol. Med., 133(2):460-462, 1970.
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Fernstrom, J.D., Larin, F., and Wurtman, R.J. Daily variations in the concentrations of individual amino acids in rat plasma. Life Sci., 10(1):813-819, 1971.
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Fernstrom, J.D., and Wurtman, R.J. Elevation of plasma tryptophan by insulin in rat. Metabolism, 21(4):337-342, 1972.[PDF]
Ross, D.S., Fernstrom, J.D., and Wurtman, R.J. The role of dietary protein in generating daily rhythms in rat liver tryptophan pyrrolase and tyrosine transaminase. Metabolism, 22(9):1175-1184, 1973.
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Lipsett, D., Madras, B.K., Wurtman, R.J., and Munro, H.M. Serum tryptophan level after carbohydrate ingestion: Selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids. Life Sci., 12(II):57-64, 1973. [PDF]
Madras, B.K., Cohen, E.L., Fernstrom, J.D., Larin, F., Munro, H.N., and Wurtman, R.J. Dietary carbohydrate increases brain tryptophan and decreases serum-free tryptophan. Nature, 244(5410):34-35, 1973.[PDF]
Ordonez, L.A., and Wurtman, R.J. Enzymes catalyzing the de novo synthesis of methyl groups in the brain and other tissues of the rat. J. Neurochem., 21:1447-1455, 1973. [PDF]
Rubin, R.A., Ordonez, L.A., and Wurtman, R.J. Physiological dependence of brain methionine and s-adenosylmethionine concentrations on serum amino acid pattern. J. Neurochem., 23:227-231, 1974. [PDF]
Madras, B.K., Cohen, E.L., Messing, R., Munro, H.N., and Wurtman, R.J. Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism, 23(12):1107-1116, 1974.[PDF]
Fernstrom, J.D., Munro, H.N., and Wurtman, R.J. Brain tryptophan in rats on a high fat diet. Nature, 265(5591):277, 1977. [PDF]
Fernstrom, J.D., Wurtman, R.J., Hammarstrom-Wiklund, Rand, W.M., Munro, H.N., and Davidson, C.S. Diurnal variations in plasma concentrations of tryptophan, tyrosine, and other neutral amino acids: Effect of dietary protein intake. Am. J. Clin. Nutr., 32:1912-1922, 1979.[PDF]
Fernstrom, J.D., Wurtman, R.J., Hammarstrom-Wiklund, Rand, W.M., Munro, H.N., Davidson, C.S. Diurnal variations in plasma neutral amino acid concentrations among patients with cirrhosis: Effect of dietary protein. Am. J. Clin. Nutr., 32:1923-1933, 1979.[PDF]
Glaeser, B.S., Melamed, E., Growdon, J.H., and Wurtman, R.J. Elevation of plasma tyrosine after a single oral dose of L-tyrosine. Life Sci., 25:265-271, 1979.[PDF]
Maher, T.J., and Wurtman, R.J. L-threonine administration increases glycine concentrations in the rat central nervous system. Life Sci., 26:1283-1286, 1980.[PDF]
Melamed, E., Glaeser, B., Growdon, J.H., and Wurtman, R.J. Plasma tyrosine in normal humans: Effects of oral tyrosine and protein-containing meals. J. Neur. Trans., 47:299-306, 1980.[PDF]
Martin-Du-Pan, R., Mauron, C., Glaeser, B., and Wurtman, R.J. Effect of various oral glucose doses on plasma neutral amino acid levels. Metabolism, 31(9):937-943, 1982.[PDF]
Yokogoshi, H., and Wurtman, R.J. Meal composition and plasma amino acid ratios: Effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism, 35(9):837-842, 1986.[PDF]
Caballero, B., Mahon, B.E., Rohr, F.J., Levy, H.L., and Wurtman, R.J. Plasma amino acid levels after single-dose aspartame consumption in phenylketonuria, mild hyperphenylalaninemia, and heterozygous state for phenylketonuria. J. Pediatrics, 109(4):668-671, 1986. [PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acid levels in obesity: Effects of insulin resistance. In: Amino Acids in Health and Diseases: New Perspectives (S. Kaufman, ed.) Alan R. Liss, Inc., New York, pp.369-382, 1987. [PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acids and insulin levels in obesity: Response to carbohydrate intake and tryptophan supplements. Metabolism, 37(7):672-676, 1988.[PDF]
Caballero, B., Gleason, R.E., and Wurtman, R.J. Plasma amino acid concentrations in healthy elderly men and women. Am. J. Clin. Nutr., 53:1249-1252, 1991.[PDF]
Wurtman, R.J. Presynaptic control of release of amine neurotransmitters by precursor levels. NIPS (Am. Physiol. Soc.), 3:158-163, 1988.[PDF]
Caballero, B., and Wurtman, R.J. Differential effects of insulin resistance on leucine and glucose kinetics in obesity. Metabolism, 40(1):51-58, 1991.[PDF]
Bogdanov, M.B., and Wurtman, R.J. Effects of systemic or oral ad libitum monosodium glutamate administration on striatal glutamate release, as measured using microdialysis in freely moving rats. Brain Res., 660:337-340, 1994. [PDF]
Wurtman, R.J., Wurtman, J.J., Regan, M.M., McDermott, J.M., Tsay, R.H., and Breu, J.J. Effects of normal meals rich in carbohydrates or proteins on the plasma tryptophan ratio. Am. J. Clin. Nutrition, 77:128-132, 2003.
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Wurtman, R.J. Tryptophan. In: Encyclopedia of Neuroscience, 3rd edition [on CD ROM] (G. Adelman, B.H. Smith, eds.) Elsevier Science, 2004.[PDF]
Cansev, M., Wurtman, R.J. Aromatic amino acids in the brain. In:Handbook of Neurochemistry and Molecular Neurobiology, Third ed., vol. 6, Chpt. 4, pp. 60-97, (A. Lajtha, ed.), Springer-Verlag, Berlin, Heidelberg, 2007. [PDF]
Wang, L., Maher, T.J., Wurtman, R.J. Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid. FASEB 21:1227-1232, 2007. [PDF]
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Choline/Acetylcholine/Phosphatides/Fatty Acids
Cohen, E.L., and Wurtman, R.J. Brain acetylcholine: Increase after systemic choline administration. Life Sci., 16:1095-1102, 1975.[PDF]
Cohen, E., and Wurtman, R.J. Brain acetylcholine: Control by dietary choline. Science, 191:561-562, 1976. [PDF]
Ulus, I.H., and Wurtman, R.J. Choline Administration: Activation of tyrosine hydroxylase in dopaminergic neurons of rat brain. Science, 194:1060-1061, 1976.[PDF]
Growdon, J.H., Cohen, E.L., and Wurtman, R.J. Effects of oral choline administration on serum and CSF choline levels in patients with Huntington's Disease. J. Neurochem., 28:229-231, 1977. [PDF]
Ulus, I.H., Hirsch, M.J., and Wurtman, R.J. Trans-synaptic induction of adrenomedullary tyrosine hydroxylase activity by choline: Evidence that choline administration can increase cholinergic transmission. Proc. Natl. Acad. Sci., 74(2):798-800, 1977.[PDF]
Growdon, J.H., Gelenberg, A.J., Doller, J., Hirsch, M.J., and Wurtman, R.J. Lecithin can suppress tardive dyskinesia. New Eng. J. Med., 298:1029-1030, 1978.[PDF]
Ulus, I.H., and Wurtman, R.J. Selective response of rat peripheral sympathetic nervous system to various stimuli. J. Physiol., 293:513-523, 1979.[PDF]
Blusztajn, J.K., Zeisel, S.H., and Wurtman, R.J. Synthesis of lecithin (phosphatidylcholine) from phosphatidyl-ethanolamine in bovine brain. Brain Res., 179:319-327, 1979.[PDF]
Growdon, J.H., and Wurtman, R.J. Oral choline administration to patients with Huntington's disease. In: Advances in Neurology. (A. Barbeau, N. Wexler, and T.N. Chase, eds.) Raven Press, New York, Vol. 23:765-776, 1979.[PDF]
Zeisel, S.H., Epstein, M.F., and Wurtman, R.J. Elevated choline concentration in neonatal plasma. Life Sci., 26:1827-1831, 1980.[PDF]
Wurtman, R.J., Hefti, F., and Melamed, E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews, 32(4):315-335, 1980.[PDF]
Magil, S.G., Zeisel, S.H., and Wurtman, R.J. Effects of ingesting soy or egg lecithins on serum choline, brain choline and brain acetylcholine. J. Nutrition, 111(1):166-170, 1981.[PDF]
Blusztajn, J.K., and Wurtman, R.J. Choline biosynthesis by a preparation enriched in synaptosomes from rat brain. Nature, 290(5085):417-418, 1981.[PDF]
Zeisel, S.H., and Wurtman, R.J. Developmental changes in rat blood choline concentration. Biochem. J., 198:565-570, 1981.[PDF]
Millington, W.R., and Wurtman, R.J. Choline administration elevates brain phosphorylcholine concentrations. J. Neurochem., 38(6):1748-1752, 1982.[PDF]
Zeisel, S.H., Stanbury, J.B., Wurtman, R.J., Brigida, M.,and Fierro-Benitez, R. Choline content of mothers' milk in Ecuador and Boston. New Eng. J. Med., 306(3):175-176, 1982. [PDF]
Blusztajn, J.K., and Wurtman, R.J. Choline and cholinergic neurons. Science, 221:614-620, 1983. [PDF]
Blusztajn, J.K., Zeisel, S.H., and Wurtman, R.J. Developmental changes in the activity of phosphatidylethanolamine N-methyltransferases in rat brain. Biochem. J., 232:505-511, 1985. [PDF]
Maire, J.C., and Wurtman, R.J. Effects of electrical stimulation and choline availability on the release and contents of acetylcholine and choline in superfused slices from rat striatum. J. Physiol., 80:189-195, 1985. [PDF]
Liscovitch, M., Freese, A., Blusztajn, J.K., and Wurtman, R.J. High-performance liquid chromatography of water-soluble choline metabolites. Analyt. Biochem., 151:182-187, 1985. [PDF]
Tacconi, M.T., and Wurtman, R.J. Rat brain phosphatidyl-N,N-dimethylethanolamine is rich in polyunsaturated fatty acids. J. Neurochem., 45(3):805-809, 1985.[PDF]
Tacconi, M.T., and Wurtman, R.J. Phosphatidylcholine produced in rat synaptosomes by N-methylation is enriched in polyunsaturated fatty acids. Proc. Natl. Acad. Sci., 82:4828-4831, 1985.[PDF]
Lopez G.-C., I., Agut, J., and Wurtman, R.J. Effect of cytidine(5')diphosphocholine (CDP-choline) on the total urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) by rats and humans. J. Neural Trans., 66:129-134, 1986.[PDF]
Liscovitch, M., Freese, A., Blusztajn, J.K., and Wurtman, R.J. Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: Stimulation by phorbol esters. J. Neurochem., 47(6):1936-1941, 1986.[PDF]
Conlay, L.A., Wurtman, R.J., Blusztajn, J.K., Lopez G.-Coviella, I., Maher, T.J., and Evoniuk, G.E. Decreased plasma choline concentrations in marathon runners. New Eng. J. Med., 315:892, 1986. [PDF]
Liscovitch, M., Blusztajn, J.K., Freese, A., and Wurtman, R.J. Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate. Biochem. J., 241:81-86, 1987.[PDF]
Lakher, M., and Wurtman, R.J. In vivo synthesis of phosphatidylcholine in rat brain via the phospholipid methylation pathway. Brain Res., 419:131-140, 1987.[PDF]
Lakher, M.B., and Wurtman, R.J. Molecular composition of the phosphatidylcholines produced by the phospholipid methylation pathway in rat brain in vivo. Biochem. J., 244:325-330, 1987.[PDF]
Lopez G.-C., I., Agut, J., Von Borstel, R., and Wurtman, R.J. Metabolism of cytidine (5')-diphosphocholine (CDP-choline) following oral and intravenous administration to the human and the rat. Neurochem. Int., 11(3):293-297, 1987.[PDF]
Liscovitch, M., Slack, B., Blusztajn, J.K., and Wurtman, R.J. Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells. J. Biol. Chem., 262(36):17487-17491, 1987.[PDF]
Holbrook, P.G., and Wurtman, R.J. Presence of base-exchange activity in rat brain nerve endings: Dependence on soluble substrate concentrations and effect of cations. J. Neurochem., 50:156-162, 1988. [PDF]
Wurtman, R.J. Presynaptic control of release of amine neurotransmitters by precursor levels. NIPS (Am. Physiol. Soc.), 3:158-163, 1988.[PDF]
Ulus, I.H., Wurtman, R.J., Mauron, C., and Blusztajn, J.K. Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Res., 484:217-227, 1989.[PDF]
Slack, B.E., Liscovitch, M., Blusztajn, and Wurtman, R.J. Uptake of exogenous phosphatidylserine by human neuroblastoma cells stimulates the incorporation of [methyl-14C]Choline into Phosphatidylcholine. J. Neurochem., 53(2)472-481, 1989.[PDF]
Buyukuysal, R.L., and Wurtman, R.J. 4-aminopyridine increases acetylcholine release without diminishing membrane phosphatidylcholine. J. Neurochem., 54(4):1302-1309, 1990. [PDF]
Blusztajn, J.K., Growdon, J.H., Lee, H.-C., Liscovitch, M., Logue, M., Lopez, G.-Coviella, I., Mauron, C., Richardson, U.I., Ulus, I., and Wurtman, R.J. Abnormal phospholipid turnover and pathophysiology of Alzheimer's disease. Bulletin of Clin. Neurosci., 55:91-98, 1990.[PDF]
Buyukuysal, R.L., Holmes, T.C., and Wurtman, R.J. Interactions of 3,4-diaminopyridine and choline in stimulating acetylcholine release and protecting membrane phospholipids. Brain Res., 541:1-6, 1991.[PDF]
Sandmann, J., Peralta, E.G., and Wurtman, R.J. Coupling of transfected muscarinic acetylcholine receptor subtypes to phospholipase D. J. Biol. Chem., 266(10):6031-6034, 1991.[PDF]
Lopez, G.-Coviella, I., and Wurtman, R.J. Enhancement by cytidine of membrane phospholipid synthesis. J. Neurochem., 59(1):338-343, 1992. [PDF]
Lopez, G.-Coviella, I., Agut, J., Ortiz, J.A., and Wurtman, R.J. Effects of orally administered cytidine 5'diphosphate choline on brain phospholipid content. J. Nutr. Biochem., 3:313-315, 1992.[PDF]
Ulus, I.H., Buyukuysal, R.L., and Wurtman, R.J. N-methyl-d-aspartate increases acetylcholine release from rat striatum and cortex: Its effect is augmented by choline. J. Pharm. Exp. Therap., 261(3):1122-1128, 1992.[PDF]
Johnson, D.A., Ulus, I.H., and Wurtman, R.J. Caffeine potentiates the enhancement by choline of striatal acetylcholine release. Life Sci., 51:1597-1601, 1992.[PDF]
Nitsch, R.M., Slack, B.E., Wurtman, R.J., Growdon, J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science, 258:304-307, 1992.[PDF]
Slack, B.E., Nitsch, R.M., Livneh, E., Kunz, G.M., Breu, J., Eldar, H., and Wurtman, R.J. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase Ca. J. Biol. Chem., 268(28):21097-21101, 1993.[PDF]
Farber, S.A., Kischka, U., Marshall, D.L., and Wurtman, R.J. Potentiation by choline of basal and electrically evoked acetylcholine release, as studied using a novel device which both stimulates and perfuses rat corpus striatum. Brain Res., 607:177-184, 1993. [PDF]
Nitsch, R.M., Blusztajn, J.K., Doyle, F.M., Robitaille, Y., Wurtman, R.J., Growdon, J.H., and Kish, S.J. Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy. Neurosci. Lett., 161:191-194, 1993.[PDF]
Jackson, D.A., Kischka, U., and Wurtman, R.J. Choline enhances scopolamine-induced acetylcholine release in dorsal hippocampus of conscious, freely-moving rats. Life Sci., 56(1):45-49, 1995. [PDF]
Slack, B.E., Breu, J., Livneh, E., Eldar, H., and Wurtman, R.J. Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase Ca. Biochem. J., 305:621-626, 1995.[PDF]
Savci, V., and Wurtman, R.J. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J. Neurochem., 64(1):378-384, 1995. [PDF]
Lopez G.-Coviella, I., Agut, J., Savci, V., Ortiz, J.A., and Wurtman, R.J. Evidence that 5'-Cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels. J. Neurochem., 65(2):889-894, 1995.[PDF]
Farber, S.A., Savci, V., Wei, A., Slack, B.E., Wurtman, R.J. Choline's phosphorylation in rat striatal slices is regulated by the activity of cholinergic neurons. Brain Res., 723:90-99, 1996. [PDF]
Spiers, P.A., Myers, D., Hochanadel, G.S., Lieberman, H.R., and Wurtman, R.J. Citicoline improves verbal memory in aging. Arch. Neurol., 53:441-448, 1996.[PDF]
Cohen, B.C., Renshaw, P.F., Stoll, A.L., Wurtman, R.M., Yurgelun-Todd, D., Babb, S.M. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA, 274(11):902-907,1995. [PDF]
Babb, S.M., Appelmans, K.E., Renshaw, P.F., Wurtman, R.J., Cohen, B.M. Differential effect of CDP-choline on brain cystolic choline levels in younger and older subjects as measured by proton magnetic resonance spectroscopy. Psychopharmacology 127:88-94, 1996. [PDF]
Araki, W., and Wurtman, R.J. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc. Natl. Acad. Sci., 94:11946-11950, 1997.[PDF]
Li, J., and Wurtman, R.J. Nerve growth factor stimulates diacylglycerol de novo synthesis and phosphatidylinositol hydrolysis in pheochromocytoma cells. Brain Res., 803:44-53, 1998.[PDF]
Li, J., and Wurtman, R.J. Mechanisms whereby nerve growth factor increases diacylglycerol levels in differentiating PC12 cells. Brain Res., 818:252-259, 1999.[PDF]
Li, J., and Wurtman, R.J. Heterogeneous long chain Acyl-CoA synthetases control distribution of individual fatty acids in newly-formed glycerolipids of neuronal cells undergoing neurite outgrowth. Neurochem. Res., 24(6):739-750, 1999.[PDF]
Wurtman, R.J., Regan, M., Ulus, I., and Yu, L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem. Pharm., 60:989-992, 2000.[PDF]
Teather, L.A., Lee, R., and Wurtman, R.J. Platelet-activating factor increases prostaglandin E2 release from astrocyte-enriched cortical cell cultures. Brain Res. 946(1)87-95, 2002.[PDF]
Teather, L.A., Magnusson, J.E., and Wurtman, R.J. Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. Psychopharm. 163:430-433, 2002.[PDF]
Teather, L.A., Magnusson, J.E., Chow, C.M., and Wurtman, R.J. Environmental conditions influence hippocampal-dependent behaviors and brain levels of amyloid precursor protein. Eur. J. Neurosci. 16:2405-2415,2002.[PDF]
Richardson, U.I., Watkins, C.J., Pierre, C., Ulus, I.H., and Wurtman, R.J. Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells Brain Research, 971(2):161-167, 2003.[PDF]
Teather, L.A., and Wurtman, R.J. Cyclooxygenase-2 mediates platelet-activating factor-induced Prostaglandin E2 release from rat primary astrocytes. Neuroscience Letters 340:177-180, 2003.[PDF]
Wurtman, R.J., Wurtman, J.J., Regan, M.M., McDermott, J.M., Tsay, R.H., and Breu, J.J. Effects of normal meals rich in carbohydrates or proteins on the plasma tryptophan ratio. Am. J. Clin. Nutrition, 77:128-132, 2003. [PDF]
Teather, L.A., and Wurtman, R.J. DIetary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats. Learning and Memory. 12:39-43, 2005. [PDF]
Teather, L.A. and Wurtman, R.J. Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats. Progress in Neuro-Psychopharm. & Biological Psychiatry 27:711-717, 2003. [PDF]
Pooler, A.M., Guez, D.H., Benedictus, R., and Wurtman, R.J. Uridine enhances neurite outgrowth in NGH-differentiated PC12 cells. Neurosci. 134: 206-214, 2005.[PDF]
Wang, L., Pooler, A.M., Albrecht, M.A., and Wurtman, R.J. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J. Molecular Neurosci 27:137-145, 2005. [PDF]
Cansev, M., Watkins, C.J., van der Beek, E.M., Wurtman, R.J. Oral Uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Research 1058:101-108, 2005. [PDF]
Richard J Wurtman, Ismail H Ulus, M.D., Ph.D. Mehmet Cansev, M.D., Ph.D. Carol J Watkins, M.S., Lei Wang, Ph.D.; George Marzloff. Synaptic Proteins and Phospholipids are Increased in Gerbil Brain by Administering Uridine Plus Docosahexaenoic Acid Orally. Brain Research 1088(1):83-92, 2006. [PDF]
Pooler, A.M., Xi, S.C., Wurtman, R.J. The 3-hydrox-3-methyglutary co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. J. Neurochem. 97:716-723, 2006. [PDF]
Ulus, I.H., Watkins, C.J., Cansev, M., Wurtman, R.J. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cellular and Molecular Neurobiology Vol 26, Nos. 4-6:563-577, 2006. [PDF]
Teather, L.A., Wurtman, R.J. Platelet-activating factor affects nociception in rats at cerebral sites of action. Molecular Pain submitted, 2008. [PDF]
Wurtman, R.J., Cansev, M., Ulus, I.H. Choline and its products acetylcholine and phosphatidylcholine. Handbook of Neurochemistry, Vol. 8, Chpt. 3.2, pp._____, 2008. [PDF]
Wang, L., Albrecht, M.A., Wurtman, R.J. Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat. Brain Research 1133:42-48, 2007. [PDF]
Cansev, M., Wurtman, R.J. Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine increases brain phosphatide and synaptic proteins levels in gerbils. Neuroscience, 148:421-431, 2007. [PDF]
Sakamoto, T., Cansev, M., Wurtman, R.J. Oral supplementation with docosahexanoic acid and uridine 5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Research, 1182:50-59, 2007. [PDF]
Teather LA, Wurtman RJ. Chronic administration of UMP ameliorates the impairment of hippocampal-dependent memory in impoverished rats. J. Nutr.136:2834-2837, 2006. [PDF]
Richardson, U.I., Wurtman, R.J. Polyunsaturated fatty acids stimulate phosphatidycholine synthesis in PC12 cells. Biochimica et Biophysica Acta. online, 2007. [PDF]
Holguin, S., Martinez, J., Chow, C., Wurtman, R. Dietary uridine enhances the improvement in learning and memory produced by administering DHA plus choline to gerbils. FASEB 22:3938-3946, 2008. [PDF]
Holguin, S., Huang, Y., Liu, J., Wurtman, R. Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats. Behavioural Brain Research, 191:11-16, 2008. [PDF]
Wurtman, R. Synapse formation and cognitive brain development: effect of docosahezxaenoic acid and other dietary constituents. Metabolism 57(2):S6-S10, 2008. [PDF]
Wurtman, R.J., Cansev, M., Sakamoto, T., Ulus, I.H. Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. Omega-3 Fatty Acids, the Brain and Retina. In: World Review of Nutrition and Dietetics (A.P. Simopoulos, N.G. Gazan, eds.), Karger, Basel, Vol. 99, pp. S153-S168, 2008. [PDF]
Cansev M., Marzloff, G., Sakamoto, T., Ulus, I.H., Wurtman, R.J. Giving uridine plus docosahexaenoic acid supplementation orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Developmental Neuroscience, 31:181-192, 2009. [PDF]
Wurtman, R.J., Cansev, M., Ulus, I.H. Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides. The Journal of Nutrition, Health & Aging Vol. 13, No. 3, 2009. [PDF]
Wurtman, R.J. Use of phosphatide precursors to promote synaptogenesis. Annual Reviews of Nutrition Vol. 29, 59-87. 2009. [PDF]
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Clinical
Zacharias, L., and Wurtman, R.J. Blindness: Its relation to age of menarche. Science, 144(3622):1154-1155, 1964.[PDF]
Zacharias, L., and Wurtman, R.J. Age at menarche: Genetic and environmental influences. New Eng. J. Med., 280:868-875, 1969.[PDF]
Zacharias, L., and Wurtman, R.J. Blindness and menarche. Obstet. Gynecol., 33(5):603-608, 1969.[PDF]
Zacharias, L., Wurtman, R.J., and Schatzoff, M. Sexual maturation in contemporary American girls. Amer. J. Obstet. Gynecol., 108(5):833-846, 1970.[PDF]
Wurtman, R.J., and Zervas, N.T. Monoamine neurotransmitters and the pathophysiology of stroke and central nervous system trauma. J. Neurosurgery, 40(1):34-36, 1974.[PDF]
Zervas, N.T., Hori, H., Negora, M., Wurtman, R.J., Larin, F., and Lavyne, M.H. Reduction in brain dopamine following experimental cerebral ischemia. Nature, 247(5439):283-284, 1974.[PDF]
Wurtman, R.J., and Fernstrom, M.D. Control of brain monoamine synthesis by diet and plasma amino acids. Am. J. Clin. Nutr., 28:638-647, 1975.[PDF]
Lynch, H.J., Wurtman, R.J., Moskowitz, M.A., Archer, M.C., and Ho, M.H. Daily rhythm in human urinary melatonin. Science, 187:169-171, 1975.[PDF]
Wurtman, R.J. Pineal organ. In: Pediatrics. (A.M. Rudolph, ed.) Appleton-Century-Crofts, New York, pp.1693-1694, 1977.[PDF]
Growdon, J.H., Gelenberg, A.J., Doller, J., Hirsch, M.J., and Wurtman, R.J. Lecithin can suppress tardive dyskinesia. New Eng. J. Med., 298:1029-1030, 1978.[PDF]
Fernstrom, J.D., Wurtman, R.J., Hammarstrom-Wiklund, Rand, W.M., Munro, H.N., and Davidson, C.S. Diurnal variations in plasma concentrations of tryptophan, tyrosine, and other neutral amino acids: Effect of dietary protein intake. Am. J. Clin. Nutr., 32:1912-1922, 1979.[PDF]
Fernstrom, J.D., Wurtman, R.J., Hammarstrom-Wiklund, Rand, W.M., Munro, H.N., Davidson, C.S. Diurnal variations in plasma neutral amino acid concentrations among patients with cirrhosis: Effect of dietary protein. Am. J. Clin. Nutr., 32:1923-1933, 1979.[PDF]
Growdon, J.H., and Wurtman, R.J. Oral choline administration to patients with Huntington's disease. In: Advances in Neurology. (A. Barbeau, N. Wexler, and T.N. Chase, eds.) Raven Press, New York, Vol. 23:765-776, 1979.[PDF]
Zeisel, S.H., Epstein, M.F., and Wurtman, R.J. Elevated choline concentration in neonatal plasma. Life Sci., 26:1827-1831, 1980.[PDF]
Gelenberg, A.J., Wojcik, J.D., Growdon, J.H., Sved, A.F., and Wurtman, R.J. Tyrosine for the treatment of depression. Am. J. Psychiatry, 137(5):622-623, 1980. [PDF]
Spindel, E.R., Wurtman, R.J., and Bird, E.D. Increased TRH content of the basal ganglia in Huntington's disease. New Eng. J. Med., 303:1235-1236, 1980. [PDF]
McCall, A.L., Millington, W.R., and Wurtman, R.J. Blood-brain barrier transport of caffeine: Dose-related restriction of adenine transport. Life Sci., 31:2079-2715, 1982.[PDF]
Growdon, J.H., Melamed, E., Logue, M., Hefti, F., and Wurtman, R.J. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. Life Sci., 30:827-832, 1982.[PDF]
Martin-Du-Pan, R., Mauron, C., Glaeser, B., and Wurtman, R.J. Effect of various oral glucose doses on plasma neutral amino acid levels. Metabolism, 31(9):937-943, 1982.[PDF]
McCall, A.L., Millington, W.R., and Wurtman, R.J. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus. Proc. Natl. Acad. Sci., 79:5406-5410, 1982.[PDF]
von Borstel, R.W., Wurtman, R.J., and Conlay, L.A. Chronic caffeine consumption potentiates the hypotensive action of circulating adenosine. Life Sci., 32:1151-1158, 1983. [PDF]
Glaeser, B.S., Maher, T.J., and Wurtman, R.J. Changes in brain levels of acidic, basic, and neutral amino acids after consumption of single meals containing proportions of protein. J. Neurochem., 41(4):1016-1021, 1983.[PDF]
Spindel, E.R., Wurtman, R.J., McCall, A., Carr, D.B., Conlay, L., Griffith, L., and Arnold, M.A. Neuroendocrine effects of caffeine in normal subjects. Clin. Pharm. Therap., 36(3):402-407, 1984.[PDF]
Lieberman, H.R., Waldhauser, F., Garfield, G., Lynch, H.J., and Wurtman, R.J. Effects of melatonin on human mood and performance. Brain Res., 323:201-207, 1984.[PDF]
von Borstel, R.W., Renshaw, A.A., and Wurtman, R.J. Adenosine strongly potentiates pressor responses to nicotine in rats. Proc. Natl. Acad. Sci., 81:5599-5603, 1984.[PDF]
Maher, T.J., Glaeser, B., and Wurtman, R.J. Diurnal variations in plasma concentrations of basic and neutral amino acids and in red cell concentrations of aspartate and glutamate: effects of dietary protein intake. Am. J. Clin. Nutr., 39:722-729, 1984. [PDF]
Heraief, E., Burckhardt, P., Wurtman, J.J., and Wurtman, R.J. Tryptophan administration may enhance weight loss by some moderately obese patients on a protein-sparing modified fast (PSMF) diet. Int. J. Eating Disorders, 4:281-292, 1985.[PDF]
Wurtman, J.J., Wurtman, R.J., Mark, S., Tsay, R., Gilbert, W., Growdon, J. D-fenfluramine selectively suppresses carbohydrate snacking by obese subjects. Int. J. Eating Disorders, 4(1):89-99, 1985.[PDF]
Lieberman, H.R., Corkin, S., Spring, B.J., Wurtman, R.J., and Growdon, J.H. The effects of dietary neurotransmitter precursors on human behavior. Am. J. Clin. Nutri., 42:366-370, 1985. [PDF]
Evoniuk, G.E., von Borstel, R.W., and Wurtman, R.J. Adenosine affects sympathetic neurotransmission at multiple sites in vivo. J. Pharmacol. Exp. Ther., 236(2):350-355, 1986. [PDF]
Conlay, L.A., Wurtman, R.J., Blusztajn, J.K., Lopez G.-Coviella, I., Maher, T.J., and Evoniuk, G.E. Decreased plasma choline concentrations in marathon runners. New Eng. J. Med., 315:892, 1986. [PDF]
Lieberman, H.R., Wurtman, R.J., Emde, G.G., and Coviella, I.L.G. The effects of caffeine and aspirin onmood and performance. J. Clin. Psychopharm., 75(5):315-320, 1987.[PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acid levels in obesity: Effects of insulin resistance. In: Amino Acids in Health and Diseases: New Perspectives (S. Kaufman, ed.) Alan R. Liss, Inc., New York, pp.369-382, 1987. [PDF]
Evoniuk, G., Jacobson, K.A., Shamim, M.T., Daly, J.W., and Wurtman, R.J. A1 and A2-selective adenosine antagonists: In Vivo characterization of cardiovascular effects. J. Pharmacol. Exp. Ther., 242(3):882-887, 1987. [PDF]
Conlay, L.A., Evoniuk, G., and Wurtman, R.J. Endogenous adenosine and hemorrhagic shock: Effects of caffeine administration or caffeine withdrawal. Proc. Natl. Acad. Sci., 85:4483-4485, 1988. [PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acids and insulin levels in obesity: Response to carbohydrate intake and tryptophan supplements. Metabolism, 37(7):672-676, 1988.[PDF]
Wurtman, R.J., Caballero, B., and Salzman, E. Facilitation of levodopa-induced dyskinesias by dietary carbohydrates. New Eng. J. Med., 319:1288-1289, 1988.[PDF]
Wurtman, J.J., Brzezinski, A., Wurtman, R.J., and Laferrere, B. Effect of nutrient intake on premenstrual depression. Am. J. Obstet. Gynecol., 161(5):1228-1234, 1989.[PDF]
Wurtman, R.J., and Wurtman, J.J. Carbohydrates and depression. Sci. Am., 260(1):68-75, 1989.[PDF]
Brzezinski, A.A., Wurtman, J.J., Wurtman, R.J., Gleason, R., Greenfield, J., and Nader, T. d-fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstet. & Gynecol., 76(2):296-391, 1990. [PDF]
Growdon, J.H., Nader, T.M., Schoenfeld, J., and Wurtman, R.J. L-threonine in the treatment of spasticity. Clin. Neuropharm., 14(5):403-412, 1991.[PDF]
Spring, B., Wurtman, J., Gleason, R., Kessler, K., and Wurtman, R.J. Weight gain and withdrawal symptoms after smoking cessation: A preventive intervention using d-fenfluramine. Health Psychol., 10(3):216-223, 1991.[PDF]
Caballero, B., Gleason, R.E., and Wurtman, R.J. Plasma amino acid concentrations in healthy elderly men and women. Am. J. Clin. Nutr., 53:1249-1252, 1991.[PDF]
Berry, E.M., Growdon, J.H., Wurtman, J.J., Caballero, B., and Wurtman, R.J. A balanced carbohydrate: Protein diet in the management of Parkinson's disease. Neurology, 41:1295-1297, 1991.[PDF]
Caballero, B., and Wurtman, R.J. Differential effects of insulin resistance on leucine and glucose kinetics in obesity. Metabolism, 40(1):51-58, 1991. [PDF]
Nitsch, R.M., Blusztajn, J.K., Pittas, A.G., Slack, B.E., Growdon, J.H., Wurtman, R.J. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci., 89:1671-1675, 1992.[PDF]
Kaakkola, S., and Wurtman, R.J. Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study. Brain Res., 597:241-249, 1992.[PDF]
Dollins, A.B., Lynch, H.J., Wurtman, R.J., Deng, M.H., and Lieberman, H.R. Effects of illumination on human nocturnal serum melatonin levels and performance. Physiol. & Beh., 53:153-160, 1993. [PDF]
Dollins, A.B., Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., and Deng, M.H. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc. Natl. Acad. Sci., 91:1824-1828, 1994.[PDF]
Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., Ives, J.R., Dollins, A.B., Morabito, C., Matheson, J.K., and Schomer, D.L. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin. Pharm. Therap., 57(5):552-558, 1995.[PDF]
Sayegh, R., Schiff, I., Wurtman, J., Spiers, P., McDermott, J., and Wurtman, R.J. The effect of a carbohydrate-rich beverage on mood, appetite, and cognitive function in women with premenstrual syndrome. Obstet. Gynecol., 86(4)520-528, 1995.[PDF]
Spring, B., Wurtman, J., Wurtman, R., El-Khoury, A., Goldberg, McDermott, J., and Pingitore, R. Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. Am. J. Clin. Nutr., 62:1181-1187, 1995.[PDF]
Spiers, P.A., Myers, D., Hochanadel, G.S., Lieberman, H.R., and Wurtman, R.J. Citicoline improves verbal memory in aging. Arch. Neurol., 53:441-448, 1996.[PDF]
Zhdanova, I.V., Wurtman, R.J., Morabito, C., Piotrovska, V.R., and Lynch, H.J. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep, 19(5):423-431, 1996.[PDF]
Spedding, M., Ouvry, C., Millan, M., Duhault, J., Dacquet, C., and Wurtman, R.J. Neural control of dieting. Nature, 380:488, 1996. [PDF]
Conlay, L.A., Conant, J.A., deBros, F., and Wurtman, R.J. Caffeine alters plasma adenosine levels. Nature, 389:136, 1997. [PDF]
Zhdanova, I.V., and Wurtman, R.J. Efficacy of melatonin as a sleep-promoting agent. J. Biol. Rhythms, 12(6):644-650, 1997.[PDF]
Zhdanova, I., Wurtman, R.J., Balcioglu, A., Kartashov, A.I., and Lynch, H.J. Edogenous melatonin levels and the fate of exogenous melatonin: Age effects. J. Gerontology, 53A(4):B293-B298, 1998.[PDF]
Zhdanova, I.V., Wurtman, R.J., and Wagstaff, J. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J. Ped. Endocrin. Metab., 12:57-67, 1999.[PDF]
Maher, T.J., Ulus, I.H., and Wurtman, R.J. Phentermine and other monoamine-oxidase inhibitors may increase plasma serotonin when given with fenfluramines. The Lancet, 353(9146):38, 1999.[PDF]
Ulus, I.H., Maher, T.J., and Wurtman, R.J. Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem. Pharm., 59:1611-1621, 2000.[PDF]
Wurtman, R.J., Regan, M., Ulus, I., and Yu, L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem. Pharm., 60:989-992, 2000.[PDF]
Zhdanova, I.V., Wurtman, R.J., Regan, M.M., Taylor, J.A., Shi, J.P., and LeClair, O.U. Melatonin treatment for age-related insomnia. J. Clin. Endocrin. Metab., 86(10):4727-4730, 2001.[PDF]
Teather, L.A., Magnusson, J.E., Chow, C.M., and Wurtman, R.J. Environmental conditions influence hippocampal-dependent behaviors and brain levels of amyloid precursor protein. Eur. J. Neurosci. 16:2405-2415,2002.[PDF]
Wurtman, R.J., Wurtman, J.J., Regan, M.M., McDermott, J.M., Tsay, R.H., and Breu, J.J. Effects of normal meals rich in carbohydrates or proteins on the plasma tryptophan ratio. Am. J. Clin. Nutrition, 77:128-132, 2003.[PDF]
Wurtman, R.J. Genes, stress, and depression. Metabolism 54(1):16-19, 2005.[PDF]
Wurtman, J.J., McDermott, J.M., LEvendusky, P., Duca, K., and Wurtman, R.J. The effect of a novel dietary intervention on weight loss in psychotropic drug-induced obesity. Psychopharm. Bull. 36(3):55-59, 2002. [PDF]
Wurtman, R.J. Narcolepsy and the hypocretins. Metabolism:Clinical and Expermental 55(Suppl 2):S36-S39, 2006. [PDF]
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Dopa/Dopamine/Norepinephrine/Epinephrine
Wurtman, R.J., Kopin, I.J., Axelrod, J. Thyroid function and the cardiac disposition of catecholamines. Endocrin., 73:63-74, 1963.[PDF]
Wurtman, R.J., Kopin, I.J., Horst, D., and Fischer, J.E. Epinephrine and organ blood flow: Effects of hyperthyroidism, cocaine, and denervation. Amer. J. Physiol., 207(6):1247-1250, 1964.[PDF]
Wurtman, R.J. Medical Progress: Catecholamines. New Eng. J. Med., 273:637-646; 693-700, 746-753, 1965.[PDF]
Wurtman, R.J., and Axelrod, J. Adrenaline synthesis: Control by the pituitary gland and adrenal glucocorticoids. Science, 150(3702):1464-1465, 1965.[PDF]
Wurtman, R.J., and Axelrod, J. Control of Enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J. Biol. Chem., 241(10): 2301-2305, 1966.[PDF]
Wurtman, R.J. Catecholamines. Little Brown & Co., Boston, 1966.
Wurtman, R.J. Control of epinephrine synthesis in the adrenal medulla by the adrenal cortex: Hormonal specificity and dose-response characteristics. Endocrin., 79:608-614, 1966.[PDF]
Wurtman, R.J., Noble, E.P., and Axelrod, R.J. Inhibition of enzymatic synthesis of epinephrine by low doses of glucocorticoids. Endocrin., 80:825-828, 1967.[PDF]
Wurtman, R.J., Axelrod, A., and Tramezzani, J. Distribution of the adrenaline-forming enzyme in the adrenal gland of a snake, Xenodon merremii. Nature, 215(5103):879-880, 1967.[PDF]
Wurtman, R.J., Axelrod, J., Vesell, E.S., and Ross, G.T. Species differences in inducibility of phenylethanolamine-N-methyl transferase. Endocrin., 82(3): 584-590, 1968.[PDF]
Wurtman, R.J., Casper, A., Pohorecky, L.A., and Bartter, F.C. Impaired secretion of epinephrine in response to insulin among hypophysectomized dogs. Proc. Nat. Acad. Sci., 61:522-528, 1968.[PDF]
Pohorecky, L.A., Zigmond, M., Karten, H., and Wurtman, R.J. Enzymatic conversion of norepinephrine to epinephrine by the brain. J. Pharmacol. Exp. Ther., 165(2):190-195, 1969.[PDF]
Pohorecky, L.A., Piezzi, R.S., and Wurtman, R.J. Steroid induction of phenylethanolamine-N-methyl transferase in adrenomedullary explants: Independence of adrenal innvervation. Endocrin., 86(6):1466-1468, 1970.[PDF]
Wurtman, R.J., Chou, C., and Rose, C. The fate of C14-dihydroxyphenylalanine (C14-Dopa) in the whole mouse. J. Pharm. Exp. Therp., 174(3):351-356, 1970.[PDF]
Wurtman, R.J., Rose, C.M., Matthysse, S., Stephenson, J., and Baldessarini, R. L-Dihydroxyphenylalanine: Effect on S-adenosylmethionine in brain. Science, 169:395-397, 1970.[PDF]
Pohorecky, L.A., and Wurtman, R.J. Adrenocortical control of epinephrine synthesis. Pharmacol. Rev., 23(1):1-35, 1971. [PDF]
Chalmers, J.P., Baldessarini, J., and Wurtman, R.J. Effects of L-dopa on norepinephrine metabolism in the brain. Proc. Nat. Acad. Sci., 68(3):662-666, 1971.[PDF]
Shoemaker, W.J., and Wurtman, R.J. Perinatal undernutrition: Accumulation of catecholamines in rat brain. Science, 171:1017-1019, 1971.[PDF]
Weiss, B.F., Munro, H.M., and Wurtman, R.J. L-dopa: Disaggregation of brain polysomes and elevation of brain tryptophan. Science, 173:833-835, 1971.[PDF]
Hoeldtke, R., Baliga, B.S., Issenberg, P., and Wurtman, R.J. Dihydroxyphenylalanine in rat food containing wheat and oats. Science, 175:761-762, 1972.[PDF]
Weiss, B.F., Munro, H.N., Ordonez, L.A., and Wurtman, R.J. Dopamine: Mediator of brain polysome disaggregation after L-Dopa. Science, 177:613-616, 1972. [PDF]
Wurtman, R.J., Pohorecky, L.A., and Baliga, B.S. Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla. Pharmacol. Rev., 24(2):411-426, 1972.[PDF]
Yehuda, S., and Wurtman, R.J. Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine. Nature, 240(5382):477-478, 1972.[PDF]
Ordonez, L.A., and Wurtman, R.J. Methylation of exogenous 3,4-dihydroxyphenylalanine (L-dopa)-effects on methyl group metabolism. Biochem. Pharmacol., 191:134-137, 1973.[PDF]
Baliga, B.S., Pohorecky, L.A., Munro, H.N., and Wurtman, R.J. Control of adrenal medullary protein synthesis by corticosteroids. Biochem. Biophys. Acta, 299:337-343, 1973.[PDF]
Munro, H.N., Roel, L., and Wurtman, R.J. Inhibition of brain protein synthesis by doses of L-dopa that disaggregate brain polyribosomes. J. Neur. Trans., 34:321-323, 1973.[PDF]
Hoeldtke, R.D., and Wurtman, R.J. Synthesis of DOPA in rat stomach following ingestion of cereals. Metabolism, 23(1):25-31, 1974.[PDF]
Ordonez, L.A., Arbrus, M., Boyson, S., Goodman, M.N., Ruderman, N.B., and Wurtman, R.J. Skeletal muscle: Reservoir for exogenous L-dopa. J. Pharmacol. Exp. Ther., 190(1):187-191, 1974.[PDF]
Hoeldtke, R.D., and Wurtman, R.J. Cereal Ingestion and catecholamine excretion. Metabolism, 23(1):33-41, 1974.[PDF]
Hoeldtke, R., Rogawski, M., and Wurtman, R.J. Effect of selective destruction of central and peripheral catecholamine-containing neurons with 6-hydroxydopamine on catecholamine excretion in the rat. Br. J. Pharmac., 50:265-270, 1974.[PDF]
Ordonez, L.A., and Wurtman, R.J. Folic acid deficiency and methyl group metabolism in rat brain: Effects of L-dopa. Arch. Biochem. Biophys., 160:372-376, 1974.[PDF]
Chiel, H., Yehuda, S., and Wurtman, R.J. Development of tolerance in rats to the hypothermic effects of d-amphetamine and apomorphine. Life Sci., 14:483-488, 1974. [PDF]
Roel, L.E., Schwartz, S.A., Weiss, B.F., Munro, H.N., and Wurtman, R.J. In vivo inhibition of rat brain protein synthesis by L-dopa. J. Neurochem., 23:233-239, 1974.[PDF]
Wurtman, R.J., Larin, F., Mostafapour, S., and Fernstrom, J.D. Brain catechol synthesis: Control by brain tyrosine concentration. Science, 185:183-184, 1974.[PDF]
Moskowitz, M.A., Weiss, B.F., Lytle, L.D., Munro, H.N., and Wurtman, R.J. d-amphetamine disaggregates brain polysomes via a dopaminergic mechanism. Proc. Nat. Acad. Sci., 72(3):834-836, 1975.[PDF]
Scriabine, A., Ludden, C.T., Stone, C.A., Wurtman, R.J., and Watkins, C.J. Enhancement of the anti-hypertensive effect of methyldopa and other anti-hypertensive drugs by carbidopa in spontaneously hypertensive rats. Clin. Sci. and Molec. Med., 51:407s-410s, 1976.[PDF]
Gibson, C.J., and Wurtman, R.J. Physiological control of brain catechol synthesis by brain tyrosine concentration. Biochem. Pharm., 26:1137-1142, 1977.[PDF]
Zavisca, F.G., and Wurtman, R.J. Effects of neutral amino acids on the antihypertensive action of methyldopa in spontaneously hypertensive rats. J. Pharm. Pharmacol., 30:60-62, 1978.[PDF]
Watkins, C.J., Wiggins, J.F., and Wurtman, R.J. Carbidopa elevates hypothalamic dopa and serum prolactin in rats. Life Sci. 24:1675-1682, 1979.[PDF]
Sved, A.F., Fernstrom, J.D., and Wurtman, R.J. Tyrosine administration reduces blood pressure and enhances brain norepinephrine release in spontaneously hypertensive rats. Proc. Natl. Acad. Sci., 76(7):3511-3514, 1979.[PDF]
Zavisca, F.G., Breau, A.P., and Wurtman, R.J. Mechanism of action of methyldopa in the rat. Circ. Res., 45(5):684-690, 1979. [PDF]
Sved, A.F., Fernstrom, J.D., and Wurtman, R.J. Tyrosine administration decreases serum prolactin levels in chronically reserpinized rats. Life Sci., 25(15):1293-1299, 1979.[PDF]
Pettibone, D.J., and Wurtman, R.J. D-amphetamine reduces striatal substance P concentrations by presynaptic release of dopamine. Brain Res., 186:409-419, 1980.[PDF]
Hefti, F., Melamed, E., and Wurtman, R.J. Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization. Brain Res., 195:123-137, 1980.[PDF]
Melamed, E., Hefti, F., and Wurtman, R.J. Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. Proc. Natl. Acad. Sci., 77(7):4305-4309, 1980.[PDF]
Wurtman, R.J., Hefti, F., and Melamed, E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews, 32(4):315-335, 1980.[PDF]
Agharanya, J.C., Alonso, R., and Wurtman, R.J. Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects. Amer. J. Clin. Nutr., 34:82-87, 1981. [PDF]
Hefti, F., Melamed, E., and Wurtman, R.J. The site of dopamine formation in rat striatum after L-Dopa administration. J. Pharmacol. Exp. Ther., 217(1):189-197, 1981.[PDF]
Conlay, L.A., Maher, T.J., and Wurtman, R.J. Tyrosine increases blood pressure in hypotensive rats. Science, 212:559-560, 1981.[PDF]
Agharanya, J.C., and Wurtman, R.J. Effect of acute administration of neutral and other amino acids on urinary excretion of catecholamines. Life Sci., 30:739-746, 1982. [PDF]
Agharanya, J.C., and Wurtman, R.J. Studies on the mechanism by which tyrosine raises urinary catecholamines. Biochem. Pharm., 31(22):3577-3580, 1982.[PDF]
Alonso, R., Gibson, C., Wurtman, R.J., Agharanya, J.C., and Prieto, L. Elevation of urinary catecholamines and their metabolites following tyrosine administration in humans. Biol. Psych., 17(7):781-790, 1982.[PDF]
Oishi, T., and Wurtman, R.J. Effect of tyrosine on brain catecholamine turnover in reserpine-treated rats. J. Neural Trans., 53:101-108, 1982.[PDF]
Gibson, C.J., Watkins, C.J., and Wurtman, R.J. The effects of tyrosine and other nutrients on neurotransmitter synthesis in the brain and retina. Retina, 2(4):332-340, 1982.[PDF]
Gibson, C.J., Watkins, C.J., and Wurtman, R.J. Tyrosine administration enhances dopamine synthesis and release in light-activated rat retina. J. Neural Trans., 56:153-160, 1983.[PDF]
Conlay, L.A., Maher, T.J., Moses, P.L., and Wurtman, R.J. Tyrosine's vasoactive effect in the dog shock model depends on the animal's starting blood pressure. J. Neural Trans., 58:69-74, 1983.[PDF]
Reinstein, D.K., Lehnert, H., Scott, N.A., and Wurtman, R.J. Tyrosine prevents behavioral and neurochemical correlates of an acute stress in rats. Life Sci., 34:2225-2232, 1984.[PDF]
Milner, J.D., and Wurtman, R.J. Release of endogenous dopamine from electrically stimulated slices of rat striatum. Brain Res., 301:139-142, 1984.[PDF]
Lehnert, H., Reinstein, D.K., Strowbridge, B.W., and Wurtman, R.J. Neurochemical and behavioral consequences of acute, uncontrollable stress: Effects of dietary tyrosine. Brain Res., 303:215-223, 1984.[PDF]
Conlay, L.A., Maher, T.J., and Wurtman, R.J. Tyrosine's pressor effect in hypotensive rats is not mediated by tyramine. Life Sci., 35(11):1207-1212, 1984.[PDF]
Conlay, L.A., Maher, T.J., and Wurtman, R.J. Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats. Brain Res., 333:81-84, 1985.[PDF]
Milner, J.D., Wurtman, R.J. Tyrosine availability determines stimulus-evoked dopamine release from rat striatal slices. Neurosci. Letters, 59:215-220, 1985.[PDF]
Reinstein, D.K., Lehnert, H., and Wurtman, R.J. Dietary tyrosine suppresses the rise in plasma corticosterone following acute stress in rats. Life Sci., 37:2157-2163, 1985.[PDF]
During, M.J., Acworth, I.N., and Wurtman, R.J. Effects of systemic L-tyrosine on dopamine release from rat corpus striatum and nucleus accumbens. Brain Res., 452:378-380, 1988. [PDF]
During, M.J., Acworth, I.N., and Wurtman, R.J. Phenylalanine administration influences dopamine release in the rat's corpus striatum. Neurosci. Lett., 93:91-95, 1988. [PDF]
Godley, B.F., and Wurtman, R.J. Release of endogenous dopamine from the superfused rabbit retina in vitro: Effect of light stimulation. Brain Res., 452:393-395, 1988.[PDF]
Acworth, I.N., During, M.J., and Wurtman, R.J. Tyrosine: Effects on catecholamine release. Brain Res. Bull., 21:473-477, 1988. [PDF]
Wurtman, R.J., Caballero, B., and Salzman, E. Facilitation of levodopa-induced dyskinesias by dietary carbohydrates. New Eng. J. Med., 319:1288-1289, 1988.[PDF]
Berry, E.M., Growdon, J.H., Wurtman, J.J., Caballero, B., and Wurtman, R.J. A balanced carbohydrate: Protein diet in the management of Parkinson's disease. Neurology, 41:1295-1297, 1991.[PDF]
Kaakkola, S., and Wurtman, R.J. Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study. Brain Res., 597:241-249, 1992.[PDF]
Kaakkola, S., and Wurtman, R.J. Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. J. Neurochem., 60(1):137-144, 1993.[PDF]
Dollins, A.B., Krock, L.P., Storm, W.F., Wurtman, R.J., and Lieberman, H.R. L-tyrosine ameliorates some effects of lower body negative pressure stress. Physiol. Behav., 57(2):223-230, 1995. [PDF]
Cansev, M., Ulus, I.H., Wang, L., Maher, T.J., Wurtman, R.J. Protective effects of uridine plus docasahexaenoic acid in a rat model of Parkinson's disease. Movement disorders, in press, 2007. [PDF]
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Endocrinology
Wurtman, R.J. An effect of luteinizing hormone on the fractional perfusion of the rat ovary. Endocrin., 75(6):927-933, 1964.[PDF]
Wurtman, R.J. Stress and the adrenocortical control of epinephrine synthesis. Metabolism 51(6, Suppl 1):11-14,2002. [PDF]
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Feeding & Obesity
Wurtman, J.J., and Wurtman, R.J. Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats. Science, 198:1178-1180, 1977. [PDF]
Wurtman, J.J., and Wurtman, R.J. Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. Life Sci., 24:895-904, 1979. [PDF]
Wurtman, J.J., Moses, P.L., and Wurtman, R.J. Prior carbohydrate consumption affects the amount of carbohydrate that rats choose to eat. J. Nutr., 113:70-78, 1983.[PDF]
Moses, P.L., and Wurtman, R.J. The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet. Life Sci., 35:1297-1300, 1984.[PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acid levels in obesity: Effects of insulin resistance. In: Amino Acids in Health and Diseases: New Perspectives (S. Kaufman, ed.) Alan R. Liss, Inc., New York, pp.369-382, 1987. [PDF]
Caballero, B., Finer, N., and Wurtman, R.J. Plasma amino acids and insulin levels in obesity: Response to carbohydrate intake and tryptophan supplements. Metabolism, 37(7):672-676, 1988.[PDF]
Brzezinski, A.A., Wurtman, J.J., Wurtman, R.J., Gleason, R., Greenfield, J., and Nader, T. d-fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstet. & Gynecol., 76(2):296-391, 1990. [PDF]
Spring, B., Wurtman, J., Gleason, R., Kessler, K., and Wurtman, R.J. Weight gain and withdrawal symptoms after smoking cessation: A preventive intervention using d-fenfluramine. Health Psychol., 10(3):216-223, 1991.[PDF]
Caballero, B., and Wurtman, R.J. Differential effects of insulin resistance on leucine and glucose kinetics in obesity. Metabolism, 40(1):51-58, 1991. [PDF]
Sayegh, R., Schiff, I., Wurtman, J., Spiers, P., McDermott, J., and Wurtman, R.J. The effect of a carbohydrate-rich beverage on mood, appetite, and cognitive function in women with premenstrual syndrome. Obstet. Gynecol., 86(4):520-528, 1995.[PDF]
Spring, B., Wurtman, J., Wurtman, R., El-Khoury, A., Goldberg, McDermott, J., and Pingitore, R. Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. Am. J. Clin. Nutr., 62:1181-1187, 1995.[PDF]
Spedding, M., Ouvry, C., Millan, M., Duhault, J., Dacquet, C., and Wurtman, R.J. Neural control of dieting. Nature, 380:488, 1996.[PDF]
Arjona, A.A., Zhang, S.X., Adamson, B., and Wurtman, R.J. An animal model of antipsychotic-induced weight gain. Behav. Brain Res., 152:121-127, 2004.[PDF]
Wurtman, J.J., McDermott, J.M., Levendusky, P., Duca, K., and Wurtman, R.J. The effect of a novel dietary intervention on weight loss in psychotropic drug-induced obesity. Psychopharm. Bull. 36(3):55-59, 2002. [PDF]
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Light
Wurtman, R.J., and Neer, R.M. Editorial: Good light and bad. New Eng. J. Med., 282:394-395, 1970.[PDF]
Neer, R.M., Davis, T.R.A., Walcott, A., Koski, S., Schepis, P., Taylor, I., Thorington, L., and Wurtman, R.J. Stimulation by artificial lighting of calcium absorption in elderly human subjects. Nature, 229:255-257, 1971.[PDF]
Wurtman, R.J. The effects of light on the human body. Sci. Am., 233(1):69-77, 1975.[PDF]
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Medical History
Wurtman, R.J., and Bettiker, R.L. The slowing of treatment discover, 1965-1995. Nature Med., 1(11):1122-1125, 1995.[PDF]
Wurtman, R.J. What went right: Why is HIV a treatable infection? Nature Med., 3(7):714-717, 1997.[PDF]
Wurtman, R.J. Curbside Consultation: Tossed in Translation. Harvard Medical Alumni BulletinSummer 2005.[PDF]
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Melatonin
Wurtman, R.J., Altschule, M.D., and Holmgren, U. Effects of pinealectomy and of a bovine pineal extract in rats. Amer. J. Physiol., 197(1):108-110, 1959.[PDF]
Wurtman, R.J., Roth, W., Altschule, M.D., and Wurtman, J.J. Interactions of the pineal and exposure to continuous light on organ weights of female rats. Acta Endocrinologica, 36:617-624, 1961.[PDF]
Roth, W.D., Wurtman, R.J., and Altschule, M.D. Morphologic changes in the pineal parenchyma cells of rats exposed to continuous light or darkness. Endocrin., 71(6):888-892, 1962.[PDF]
Wurtman, R.J., Axelrod, J., and Chu, E.W. Melatonin, a pineal substance: Effect on the rat ovary. Science, 141(3577):277-278, 1963.[PDF]
Wurtman, R.J., Axelrod, J., and Phillips, L.S. Melatonin synthesis in the pineal gland: Control by light. Science, 142(3595):1071-1073, 1963.[PDF]
Wurtman, R.J., Axelrod, J., and Potter, L.T. The uptake of H3-melatonin in endocrine and nervous tissues and the effects of constant light exposure. J. Pharmacol. Exp. Ther., 143(3):314-318, 1964.[PDF]
Wurtman, R.J., Axelrod, J., and Fischer, J.E. Melatonin synthesis in the pineal gland: Effect of light mediated by the sympathetic nervous system. Science, 143(3612):1328-1330, 1964. [PDF]
Axelrod, J., and Wurtman, R.J. Melatonin synthesis in the hen pineal gland and its control by light. Nature, 201(4924):1134, 1964.[PDF]
Chu, E.W., Wurtman, R.J., and Axelrod, J. An inhibitory effect of melatonin on the estrous phase of the estrous cycle of the rodent. Endocrin., 75(2):238-242, 1964.[PDF]
Axelrod, J., Wurtman, R.J., and Snyder, S.H. Control of hydroxyindole-O-methyltransferase activity in the rat pineal gland by environmental lighting. J. Biol. Chem., 240:949-954, 1965.[PDF]
Snyder, S.H., Axelrod, J., Wurtman, R.J., and Fischer, J.E. Control of 5-hydroxytryptophan decarboxylase activity in the rat pineal gland by sympathetic nerves. J. Pharmacol. Exp. Ther., 147(3):371-375, 1965.[PDF]
Wurtman, R.J., and Axelrod, J. The pineal Gland. Sci. Amer., 213(1):50-60, 1965.[PDF]
Wurtman, R.J., and Axelrod, J. Effect of chlorpromazine and other drugs on the disposition of circulating melatonin. Nature, 212(5059):312, 1966.[PDF]
Shein, H.M., Wurtman, R.J., and Axelrod, J. Synthesis of serotonin by pineal glands of the rat in organ culture. Nature, 213(5077):730-731, 1967.[PDF]
Moore, R.Y., Heller, A., Wurtman, R.J., and Axelrod, J. Visual pathway mediating pineal response to environmental light. Science, 155(3759):220-223, 1967.[PDF]
Wurtman, R.J., Axelrod, J., Sedvall, G., and dick/www, R.Y. Photic and neural control of the 24-hour norepinephrine rhythm in the rat pineal gland. J. Pharmacol. Exp. Ther., 157(3):487-492, 1967.[PDF]
Wurtman, R.J., Axelrod, J., and Anton-Tay, F. Inhibition of the metabolism of H3-melatonin by phenothiazines. J. Pharmacol. Exp. Ther., 161(2):367-372, 1968.[PDF]
Wurtman, R.J., Axelrod, J., and Kelly, D.E. The Pineal, Academic Press, New York, 1968. Anton-Tay, F., Chou, C., Anton, S., and Wurtman, R.J. Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin. Science, 162:277-278, 1968.[PDF]
Wurtman, R.J., and Anton-Tay, F. The mammalian pineal as a neuroendocrine transducer. Recent Progr. Hormone Res., 25:493-522, 1969.[PDF]
Anton-Tay, F., Wurtman, R.J. Regional uptake of 3H-melatonin from blood or cerebrospinal fluid by rat brain. Nature, 221(5179):474-475, 1969.[PDF]
Axelrod, J., Shein, H.M., and Wurtman, R.J. Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Proc. Nat. Acad. Sci., 62:544-549, 1969.[PDF]
Wurtman, R.J., Shein, H.M., Axelrod, J., and Larin, F. Incorporation of 14C-tryptophan into 14C-protein by cultured rat pineals: Stimulation by i-norepinephrine. Proc. Nat. Acad. Sci., 62(3):749-755, 1969.[PDF]
Shein, H.M., and Wurtman, R.J. Cyclic adenosine monophosphate: Stimulation of melatonin and serotonin synthesis in cultured rat pineals. Science, 166:519-520, 1969.[PDF]
Wurtman, R.J., Shein, H.M., and Larin, F. Mediation by ß-adrenergic receptors of effects of norepinephrine on pineal synthesis of [14C]serotonin and [14C]melatonin. J. Neurochem., 18:1683-1687, 1971.[PDF]
Shein, H.M., and Wurtman, R.J. Stimulation of [14C]tryptophan 5-hydroxylation by norepinephrine and dibutyryl adenosine 3', 5', monophosphate in rat pineal organ cultures. Life Sci., 10(1):935-940, 1971.[PDF]
Cardinali, D.P., Larin, F., and Wurtman, R.J. Control of the rat pineal gland by light spectra. Proc. Nat. Acad. Sci., 69(8):2003-2005, 1972. [PDF]
Cardinali, D.P., Larin, F., and Wurtman, R.J. Action spectra for effects of light on hydroxyindole-O-methyl transferases in rat pineal, retina and harderian gland. Endocrin., 91(4):877-886, 1972. [PDF]
Lynch, H.J., Wang, P., and Wurtman, R.J. Increase in rat pineal melatonin content following L-dopa administration. Life Sci., 12(4):145-151, 1973.[PDF]
Lynch, H.J., Eng, J.P., and Wurtman, R.J. Control of pineal indole biosynthesis by changes in sympathetic tone caused by factors other than environmental lighting. Proc. Nat. Acad. Sci., 70(6):1704-1707, 1973.[PDF]
Lynch, H.J., Wurtman, R.J., Moskowitz, M.A., Archer, M.C., and Ho, M.H. Daily rhythm in human urinary melatonin. Science, 187:169-171, 1975.[PDF]
Jimerson, D.C., Lynch, H.J., Post, R.M., Wurtman, R.J., and Bunney, Jr., W.E. Urinary melatonin rhythms during sleep deprivation in depressed patients and normals. Life Sci., 20:1501-1508, 1977.[PDF]
Waldhauser, F., Waldhauser, M., Liberian, H.R., Deng, M.H., Lynch, H.J., and Wurtman, R.J. Bioavailability of oral melatonin in humans. Neuroendocrin., 39:307-313, 1984.[PDF]
Waldhauser, F.W., Weizenbacher, G., Frisch, H., Zeitlhuber, U., Waldhauser, M., and Wurtman, R.J. Fall in nocturnal serum melatonin during prepuberty and pubescence. The Lancet, February, 362-365, 1984.[PDF]
Lieberman, H.R., Waldhauser, F., Garfield, G., Lynch, H.J., and Wurtman, R.J. Effects of melatonin on human mood and performance. Brain Res., 323:201-207, 1984.[PDF]
Brzezinski, A., Seibel, M.M., Lynch, H.J., Deng, M.H., and Wurtman, R.J. Melatonin in human preovulatory follicular fluid. J. Clin. Endocrin. Metab., 64(4):865-867, 1987. [PDF]
Brzezinski, A., Lynch, H.J., and Wurtman, R.J. Possible contribution of melatonin to the timing of the luteinizing hormone surge. New Eng. J. Med., 316:1550-1551, 1987. [PDF]
Brzezinski, A., and Wurtman, R.J. The pineal gland: Its possible roles in human reproduction. Obstetrical & Gynecological Survey, 43(4):197-207, 1988.[PDF]
Brzezinski, A., Lynch, H.J., Seibel, M.M., Deng, M.H., Nader, T.M., and Wurtman, R.J. The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women. J. Clin. Endocrin. Metab., 66(5):891-895, 1988.[PDF]
O'Rourke, D., Wurtman, J.J., Wurtman, R.J., Chebli, R., and Gleason, R. Treatment of seasonal depression with d-fenfluramine. J. Clin. Psychiatry, 50(9):343-347, 1989.[PDF]
Dollins, A.B., Lynch, H.J., Wurtman, R.J., Deng, M.H., and Lieberman, H.R. Effects of illumination on human nocturnal serum melatonin levels and performance. Physiol. & Beh., 53:153-160, 1993. [PDF]
Dollins, A.B., Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., and Deng, M.H. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc. Natl. Acad. Sci., 91:1824-1828, 1994.[PDF]
Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., Ives, J.R., Dollins, A.B., Morabito, C., Matheson, J.K., and Schomer, D.L. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin. Pharm. Therap., 57(5):552-558, 1995.[PDF]
Zhdanova, I.V., Wurtman, R.J., Morabito, C., Piotrovska, V.R., and Lynch, H.J. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep, 19(5):423-431, 1996.[PDF]
Zhdanova, I.V., and Wurtman, R.J. Efficacy of melatonin as a sleep-promoting agent. J. Biol. Rhythms, 12(6):644-650, 1997.[PDF]
Zhdanova, I., Wurtman, R.J., Balcioglu, A., Kartashov, A.I., and Lynch, H.J. Edogenous melatonin levels and the fate of exogenous melatonin: Age effects. J. Gerontology, 53A(4):B293-B298, 1998.[PDF]
Zhdanova, I.V., Wurtman, R.J., and Wagstaff, J. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J. Ped. Endocrin. Metab., 12:57-67, 1999.[PDF]
Zhdanova, I.V., Wurtman, R.J., Regan, M.M., Taylor, J.A., Shi, J.P., and LeClair, O.U. Melatonin treatment for age-related insomnia. J. Clin. Endocrin. Metab., 86(10):4727-4730, 2001.[PDF]
Wurtman, R.J. Melatonin. In: Encyclopedia of Neuroscience, 3rd edition [on CD ROM] (G. Adelman, B.H. Smith, eds.) Elsevier Science, 2004.[PDF]
Brzezinski, A., Ducherty, G., Zhdanova, I.V., Wurtman, R.J., and Ford, I. Effect of exogenous melatonin on sleep - a meta-analysis of 14 controlled clinical trials. Sleep Medicine Reviews 9:41-50, 2005.[PDF]
Wurtman, R.J. Melatonin in: Encyclopedia of Dietary Supplements (P. Coates, et al. eds), Marcel Dekker, Inc. (In Press, Galley Proof), 2005. [PDF]
Wurtman, R.J. Ramelteon, a novel treatment for the treatment of insomnia. Expert Rev. Neurotherapeutics 6(7):957-964, 2006 [PDF]
Wurtman, R.J Ramelteon: A melatonin receptor agonist. Sleep Pharmacology:Basic Science and Clinical Applications in press, 2008 [PDF]
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Serotonin
Wurtman, R.J., and Axelrod, J. A sensitive and specific assay for the estimation of monoamine oxidase. Biochem. Pharmacol., 12:1439-1440, 1963.[PDF]
Fernstrom, J.D., and Wurtman, R.J. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science, 173:149-152, 1971. [PDF]
Fernstrom, J.D., and Wurtman, R.J. Effect of chronic corn consumption on serotonin content of rat brain. Nature New Biol., 234(45):62-64, 1971.[PDF]
Fernstrom, J.D., and Wurtman, R.J. Brain serotonin content: Increase following ingestion of carbohydrate diet. Science, 174:1023-1025, 1971.[PDF]
Fernstrom, J.D., and Wurtman, R.J. Brain serotonin content: Physiological regulation by plasma neutral amino acids. Science, 178:414-416, 1972.[PDF]
Weiss, B.F., Wurtman, R.J., and Munro, H.N. Disaggregation of brain polysomes by L-5-hydroxytryptophan: Mediation by serotonin. Life Sci., 13:411-416, 1973.[PDF]
Wurtman, J.J., and Wurtman, R.J. Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. Life Sci., 24:895-904, 1979. [PDF]
Wurtman, R.J., Hefti, F., and Melamed, E. Precursor control of neurotransmitter synthesis. Pharmacological Reviews, 32(4):315-335, 1980.[PDF]
Chiel, H.J., and Wurtman, R.J. Short-term variations in diet composition change the pattern of spontaneous motor activity in rats. Science, 213:676-678, 1981.[PDF]
Lieberman, H.R., Corkin, S., Spring, B.J., Growdon, J.H., and Wurtman, R.J. Mood, performance, and pain sensitivity: Changes induced by food constituents. J. Psychiat. Res., 17(2):135-145, 1982/1983.[PDF]
Wurtman, J.J., Wurtman, R.J., Mark, S., Tsay, R., Gilbert, W., Growdon, J. D-fenfluramine selectively suppresses carbohydrate snacking by obese subjects. Int. J. Eating Disorders, 4(1):89-99, 1985.[PDF]
Yokogoshi, H., and Wurtman, R.J. Meal composition and plasma amino acid ratios: Effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism, 35(9):837-842, 1986.[PDF]
Wurtman, R.J. Presynaptic control of release of amine neurotransmitters by precursor levels. NIPS (Am. Physiol. Soc.), 3:158-163, 1988.[PDF]
Wurtman, R.J., and Wurtman, J.J. Carbohydrates and depression. Sci. Am., 260(1):68-75, 1989.[PDF]
O'Rourke, D., Wurtman, J.J., Wurtman, R.J., Chebli, R., and Gleason, R. Treatment of seasonal depression with d-fenfluramine. J. Clin. Psychiatry, 50(9):343-347, 1989.[PDF]
Laferrere, B., and Wurtman, R.J. Effect of D-fenfluramine on serotonin release in brains of anaesthetized rats. Brain Res., 504:258-263, 1989.[PDF]
Schaechter, J.D., and Wurtman, R.J. Tryptophan availability modulates serotonin release from rat hypothalamic slices. J. Neurochem., 53(6):1925-1933, 1989.[PDF]
Schaechter, J.D., and Wurtman, R.J. Effect of chronic D-fenfluramine administration on rat hypothalamic serotonin levels and release. Life Sci., 44:265-271, 1989.[PDF]
Wurtman, J.J., Brzezinski, A., Wurtman, R.J., and Laferrere, B. Effect of nutrient intake on premenstrual depression. Am. J. Obstet. Gynecol., 161(5):1228-1234, 1989.[PDF]
Schaechter, J.D., and Wurtman, R.J. Serotonin release varies with brain tryptophan levels. Brain. Res., 532:203-210, 1990.[PDF]
Brzezinski, A.A., Wurtman, J.J., Wurtman, R.J., Gleason, R., Greenfield, J., and Nader, T. d-fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstet. & Gynecol., 76(2):296-391, 1990. [PDF]
Spring, B., Wurtman, J., Gleason, R., Kessler, K., and Wurtman, R.J. Weight gain and withdrawal symptoms after smoking cessation: A preventive intervention using d-fenfluramine. Health Psychol., 10(3):216-223, 1991.[PDF]
O'Rourke, D.A., Wurtman, J.J., Wurtman, R.J., Tsay, R., Gleason, R., Baer, L., and Jenike, M.A. J. Clin. Psychiat., 55(10):445-447, 1994.[PDF]
Sayegh, R., Schiff, I., Wurtman, J., Spiers, P., McDermott, J., and Wurtman, R.J. The effect of a carbohydrate-rich beverage on mood, appetite, and cognitive function in women with premenstrual syndrome. Obstet. Gynecol., 86(4):520-528, 1995.[PDF]
Spring, B., Wurtman, J., Wurtman, R., El-Khoury, A., Goldberg, McDermott, J., and Pingitore, R. Efficacies of dexfenfluramine and fluoxetine in preventing weight gain after smoking cessation. Am. J. Clin. Nutr., 62:1181-1187, 1995.[PDF]
Spedding, M., Ouvry, C., Millan, M., Duhault, J., Dacquet, C., and Wurtman, R.J. Neural control of dieting. Nature, 380:488, 1996.[PDF]
Wurtman, J.J., McDermott, J.M., Levendusky, P., Duca, K., and Wurtman, R.J. Psychopharm. Bulletin, 36(3):55-59, 2002.[PDF]
Arjona, A.A., Pooler, A.M., Wurtman, R.J., and Lee, R.K. Effect of 5-HT2C serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in Guinea pigs. Brain Research, 951:135-140, 2002.[PDF]
Amer, A., Breu, J., McDermott, J., Wurtman, R.J., Maher, T.J. 5-Hydroxytryptophan raises plasma 5-HTP levels in humans and rats and suppresses food intake by hypophagic and stressed rats. J. Pharm., Biochem. Behav., 77:137-143, 2004. [PDF]
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