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Selected publications on melatonin

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Anton-Tay, F., Wurtman, R.J.
Regional uptake of 3H-melatonin from blood or cerebrospinal fluid by rat brain.
Nature, 221(5179):474-475, 1969.
[PDF] , PID: 107, PK: 335, Admin
Axelrod, J., Shein, H.M., and Wurtman, R.J.
Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture.
Proc. Nat. Acad. Sci., 62:544-549, 1969.
[PDF] , PID: 113, PK: 336, Admin
Axelrod, J., Wurtman, R.J., and Snyder, S.H.
Control of hydroxyindole-O-methyltransferase activity in the rat pineal gland by environmental lighting.
J. Biol. Chem., 240:949-954, 1965.
[PDF] , PID: 37, PK: 325, Admin
Axelrod, J., and Wurtman, R.J.
Melatonin synthesis in the hen pineal gland and its control by light.
Nature, 201(4924):1134, 1964.
[PDF] , PID: 23, PK: 323, Admin
Brzezinski, A., Ducherty, G., Zhdanova, I.V., Wurtman, R.J., and Ford, I.
Effect of exogenous melatonin on sleep - a meta-analysis of 14 controlled clinical trials.
Sleep Medicine Reviews, 9:41-50, 2005.
[PDF] , PID: 988, PK: 364, Admin
Brzezinski, A., Lynch, H.J., Seibel, M.M., Deng, M.H., Nader, T.M., and Wurtman, R.J.
The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women.
J. Clin. Endocrin. Metab., 66(5):891-895, 1988.
[PDF] , PID: 743, PK: 353, Admin
Brzezinski, A., Lynch, H.J., and Wurtman, R.J.
Possible contribution of melatonin to the timing of the luteinizing hormone surge.
New Eng. J. Med., 316:1550-1551, 1987.
[PDF] , PID: 719, PK: 351, Admin
Brzezinski, A., Seibel, M.M., Lynch, H.J., Deng, M.H., and Wurtman, R.J.
Melatonin in human preovulatory follicular fluid.
J. Clin. Endocrin. Metab., 64(4):865-867, 1987.
[PDF] , PID: 707, PK: 350, Admin
Brzezinski, A., and Wurtman, R.J.
The pineal gland: Its possible roles in human reproduction.
Obstetrical & Gynecological Survey, 43(4):197-207, 1988.
[PDF] , PID: 685, PK: 352, Admin
Cardinali, D.P., Larin, F., and Wurtman, R.J.
Control of the rat pineal gland by light spectra.
Proc. Nat. Acad. Sci., 69(8):2003-2005, 1972.
[PDF] , PID: 188, PK: 341, Admin
Cardinali, D.P., Larin, F., and Wurtman, R.J.
Action spectra for effects of light on hydroxyindole-O-methyl transferases in rat pineal, retina and harderian gland.
Endocrin., 91(4):877-886, 1972.
[PDF] , PID: 190, PK: 342, Admin
Chu, E.W., Wurtman, R.J., and Axelrod, J.
An inhibitory effect of melatonin on the estrous phase of the estrous cycle of the rodent.
Endocrin., 75(2):238-242, 1964.
[PDF] , PID: 24, PK: 324, Admin
Dollins, A.B., Lynch, H.J., Wurtman, R.J., Deng, M.H., and Lieberman, H.R.
Effects of illumination on human nocturnal serum melatonin levels and performance.
Physiol. & Beh., 53:153-160, 1993.
[PDF] , PID: 849, PK: 201, Admin
Dollins, A.B., Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., and Deng, M.H.
Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance.
Proc. Natl. Acad. Sci., 91:1824-1828, 1994.
[PDF] , PID: 870, PK: 202, Admin
Jimerson, D.C., Lynch, H.J., Post, R.M., Wurtman, R.J., and Bunney, Jr., W.E.
Urinary melatonin rhythms during sleep deprivation in depressed patients and normals.
Life Sci., 20:1501-1508, 1977.
[PDF] , PID: 339, PK: 346, Admin
Lieberman, H.R., Waldhauser, F., Garfield, G., Lynch, H.J., and Wurtman, R.J.
Effects of melatonin on human mood and performance.
Brain Res., 323:201-207, 1984.
[PDF] , PID: 598, PK: 177, Admin
Lynch, H.J., Eng, J.P., and Wurtman, R.J.
Control of pineal indole biosynthesis by changes in sympathetic tone caused by factors other than environmental lighting.
Proc. Nat. Acad. Sci., 70(6):1704-1707, 1973.
[PDF] , PID: 224, PK: 344, Admin
Lynch, H.J., Wang, P., and Wurtman, R.J.
Increase in rat pineal melatonin content following L-dopa administration.
Life Sci., 12(4):145-151, 1973.
[PDF] , PID: 218, PK: 343, Admin
Lynch, H.J., Wurtman, R.J., Moskowitz, M.A., Archer, M.C., and Ho, M.H.
Daily rhythm in human urinary melatonin.
Science, 187:169-171, 1975.
[PDF] , PID: 277, PK: 161, Admin
Moore, R.Y., Heller, A., Wurtman, R.J., and Axelrod, J.
Visual pathway mediating pineal response to environmental light.
Science, 155(3759):220-223, 1967.
[PDF] , PID: 62, PK: 330, Admin
O'Rourke, D., Wurtman, J.J., Wurtman, R.J., Chebli, R., and Gleason, R.
Treatment of seasonal depression with d-fenfluramine.
J. Clin. Psychiatry, 50(9):343-347, 1989.
[PDF] , PID: 751, PK: 354, Admin
Roth, W.D., Wurtman, R.J., and Altschule, M.D.
Morphologic changes in the pineal parenchyma cells of rats exposed to continuous light or darkness.
Endocrin., 71(6):888-892, 1962.
[PDF] , PID: 9, PK: 318, Admin
Shein, H.M., Wurtman, R.J., and Axelrod, J.
Synthesis of serotonin by pineal glands of the rat in organ culture.
Nature, 213(5077):730-731, 1967.
[PDF] , PID: 60, PK: 329, Admin
Shein, H.M., and Wurtman, R.J.
Cyclic adenosine monophosphate: Stimulation of melatonin and serotonin synthesis in cultured rat pineals.
Science, 166:519-520, 1969.
[PDF] , PID: 133, PK: 338, Admin
Shein, H.M., and Wurtman, R.J.
Stimulation of [14C]tryptophan 5-hydroxylation by norepinephrine and dibutyryl adenosine 3', 5', monophosphate in rat pineal organ cultures.
Life Sci., 10(1):935-940, 1971.
[PDF] , PID: 169, PK: 340, Admin
Snyder, S.H., Axelrod, J., Wurtman, R.J., and Fischer, J.E.
Control of 5-hydroxytryptophan decarboxylase activity in the rat pineal gland by sympathetic nerves.
J. Pharmacol. Exp. Ther., 147(3):371-375, 1965.
[PDF] , PID: 38, PK: 326, Admin
Waldhauser, F., Waldhauser, M., Liberian, H.R., Deng, M.H., Lynch, H.J., and Wurtman, R.J.
Bioavailability of oral melatonin in humans.
Neuroendocrin., 39:307-313, 1984.
[PDF] , PID: 573, PK: 347, Admin
Waldhauser, F.W., Weizenbacher, G., Frisch, H., Zeitlhuber, U., Waldhauser, M., and Wurtman, R.J.
Fall in nocturnal serum melatonin during prepuberty and pubescence.
The Lancet, February 1984:362-365, 1984.
[PDF] , PID: 574, PK: 348, Admin
Wurtman, R.J.
Melatonin.
Encyclopedia of Neuroscience, 3rd edition [on CD ROM] (G. Adelman, B.H. Smith, eds.) Elsevier Science, 2004.
[not available] , PID: 974, PK: 363, Admin
Wurtman, R.J.
Melatonin.
Encyclopedia of Dietary Supplements (P. Coates, et al. eds), Marcel Dekker, Inc. (In Press, Galley Proof), 2005.
[PDF] , PID: 1004, PK: 365, Admin
Wurtman, R.J.
Ramelteon, a novel treatment for the treatment of insomnia.
Expert Rev. Neurotherapeutics, 6(7):957-964, 2006.
[PDF] , PID: 1003, PK: 366, Admin
Wurtman, R.J.
Ramelteon: A melatonin receptor agonist.
Sleep Pharmacology: Basic Science and Clinical Applications, :, 2008.
[PDF] , PID: 1031, PK: 367, Admin
Wurtman, R.J.
Use of melatonin to promote sleep.
U.S. Neurology, 8(1):10-, 2012.
[PDF] , PID: 1049, PK: 1121, Admin
Wurtman, R.J.
Low doses of melatonin promote sleep onset and maintenance in older people: An Update.
US Neurology, 10(2):117-119, 2014.
[PDF] , PID: 1058, PK: 1140, Admin
Wurtman, R.J., Altschule, M.D., and Holmgren, U.
Effects of pinealectomy and of a bovine pineal extract in rats.
Amer. J. Physiol., 197(1):108-110, 1959.
[PDF] , PID: 3, PK: 316, Admin
Wurtman, R.J., Axelrod, J., Sedvall, G., and dick/www, R.Y.
Photic and neural control of the 24-hour norepinephrine rhythm in the rat pineal gland.
J. Pharmacol. Exp. Ther., 157(3):487-492, 1967.
[PDF] , PID: 71, PK: 331, Admin
Wurtman, R.J., Axelrod, J., and Anton-Tay, F.
Inhibition of the metabolism of H3-melatonin by phenothiazines.
J. Pharmacol. Exp. Ther., 161(2):367-372, 1968.
[PDF] , PID: 83, PK: 332, Admin
Wurtman, R.J., Axelrod, J., and Chu, E.W.
Melatonin, a pineal substance: Effect on the rat ovary.
Science, 141(3577):277-278, 1963.
[PDF] , PID: 12, PK: 319, Admin
Wurtman, R.J., Axelrod, J., and Fischer, J.E.
Melatonin synthesis in the pineal gland: Effect of light mediated by the sympathetic nervous system.
Science, 143(3612):1328-1330, 1964.
[PDF] , PID: 22, PK: 322, Admin
Wurtman, R.J., Axelrod, J., and Kelly, D.E. The Pineal, Academic Press, New York, 1968. Anton-Tay, F., Chou, C., Anton, S., and Wurtman, R.J.
Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin.
Science, 162:277-278, 1968.
[PDF] , PID: 102, PK: 333, Admin
Wurtman, R.J., Axelrod, J., and Phillips, L.S.
Melatonin synthesis in the pineal gland: Control by light.
Science, 142(3595):1071-1073, 1963.
[PDF] , PID: 17, PK: 320, Admin
Wurtman, R.J., Axelrod, J., and Potter, L.T.
The uptake of H3-melatonin in endocrine and nervous tissues and the effects of constant light exposure.
J. Pharmacol. Exp. Ther., 143(3):314-318, 1964.
[PDF] , PID: 20, PK: 321, Admin
Wurtman, R.J., Roth, W., Altschule, M.D., and Wurtman, J.J.
Interactions of the pineal and exposure to continuous light on organ weights of female rats.
Acta Endocrinologica, 36:617-624, 1961.
[PDF] , PID: 7, PK: 317, Admin
Wurtman, R.J., Shein, H.M., Axelrod, J., and Larin, F.
Incorporation of 14C-tryptophan into 14C-protein by cultured rat pineals: Stimulation by i-norepinephrine.
Proc. Nat. Acad. Sci., 62(3):749-755, 1969.
[PDF] , PID: 119, PK: 337, Admin
Wurtman, R.J., Shein, H.M., and Larin, F.
Mediation by ß-adrenergic receptors of effects of norepinephrine on pineal synthesis of [14C]serotonin and [14C]melatonin.
J. Neurochem., 18:1683-1687, 1971.
[PDF] , PID: 154, PK: 339, Admin
Wurtman, R.J., and Anton-Tay, F.
The mammalian pineal as a neuroendocrine transducer.
Recent Progr. Hormone Res., 25:493-522, 1969.
[PDF] , PID: 104, PK: 334, Admin
Wurtman, R.J., and Axelrod, J.
The pineal gland.
Sci. Amer., 213(1):50-60, 1965.
[PDF] , PID: 40, PK: 327, Admin
Wurtman, R.J., and Axelrod, J.
Effect of chlorpromazine and other drugs on the disposition of circulating melatonin.
Nature, 212(5059):312, 1966.
[PDF] , PID: 49, PK: 328, Admin
Wurtman, RJ
Physiology and clinical use of melatonin.
UpToDate, :, 2012.
[PDF] , PID: 1050, PK: 1120, Admin
Zhdanova, I., Wurtman, R.J., Balcioglu, A., Kartashov, A.I., and Lynch, H.J.
Edogenous melatonin levels and the fate of exogenous melatonin: Age effects.
J. Gerontology, 53A(4):B293-B298, 1998.
[PDF] , PID: 954, PK: 211, Admin
Zhdanova, I.V., Wurtman, R.J., Lynch, H.J., Ives, J.R., Dollins, A.B., Morabito, C., Matheson, J.K., and Schomer, D.L.
Sleep-inducing effects of low doses of melatonin ingested in the evening.
Clin. Pharm. Therap., 57(5):552-558, 1995.
[PDF] , PID: 891, PK: 203, Admin
Zhdanova, I.V., Wurtman, R.J., Morabito, C., Piotrovska, V.R., and Lynch, H.J.
Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans.
Sleep, 19(5):423-431, 1996.
[PDF] , PID: 906, PK: 207, Admin
Zhdanova, I.V., Wurtman, R.J., Regan, M.M., Taylor, J.A., Shi, J.P., and LeClair, O.U.
Melatonin treatment for age-related insomnia.
J. Clin. Endocrin. Metab., 86(10):4727-4730, 2001.
[PDF] , PID: 975, PK: 216, Admin
Zhdanova, I.V., Wurtman, R.J., and Wagstaff, J.
Effects of a low dose of melatonin on sleep in children with Angelman syndrome.
J. Ped. Endocrin. Metab., 12:57-67, 1999.
[PDF] , PID: 940, PK: 212, Admin
Zhdanova, I.V., and Wurtman, R.J.
Efficacy of melatonin as a sleep-promoting agent.
J. Biol. Rhythms, 12(6):644-650, 1997.
[PDF] , PID: 950, PK: 210, Admin