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Selected publications on Alzheimer's disease

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Arjona, A.A., Pooler, A.M., Wurtman, R.J., and Lee, R.K.
Effect of 5-HT2C serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in Guinea pigs.
Brain Research, 951:135-140, 2002.
[PDF] , PID: 985, PK: 54, Admin
Cansev M., Marzloff, G., Sakamoto, T., Ulus, I.H., Wurtman, R.J.
Giving uridine plus docosahexaenoic acid supplementation orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups.
Developmental Neuroscience, 31:181-192, 2009.
[PDF] , PID: 1037, PK: 151, Admin
Cansev, M., Orhan, F., Yaylagul, E.O., Isik, E., Turkyilmaz, M., Aydin, S., Gumus, A., Sevinc, C., Coskun, N., Ulus, I.H.
Evidence for the existence of pyrimidinergic transmission in rat brain.
Neuropharmacology, 91:77-86, 2015.
[PDF] , PID: 1057, PK: 1135, Admin
Cansev, M., Ulus, I.H., Wang, L., Maher T.J., Wurtman, R.J.
Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease.
Neuroscience Research, 62:206-209, 2008.
[PDF] , PID: 1034, PK: 62, Admin
Cansev, M., Wurtman R.J., Sakamoto, T., Ulus, I.H.
Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.
Alzheimer's & Dementia, 4:S153-S168, 2008.
[PDF] , PID: 1033, PK: 61, Admin
Farber, S.A., Nitsch, R.M., Schultz, J.G., and Wurtman, R.J.
Regulated secretion of ß-amyloid precursor protein in rat brain.
J. Neurosci., 15(11):7442-7451, 1995.
[PDF] , PID: 907, PK: 44, Admin
Hartmann, T., van Wijk, N., Wurtman, R.J., Olde Rikkert, M.G.M., Sijben, J.W.C., Soininen, H., Vellas, B., Scheltens, P.
A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease.
Journal of Alzheimer's Disease, 41:715-717, 2014.
[PDF] , PID: 1055, PK: 1136, Admin
Hung, A.Y., Haass, C., Nitsch, R.M., Qiu, W.Q., Citron, M., Wurtman, R.J., Growdon, J.H., and Selkoe, D.J.
Activation of protein kinase C inhibits cellular production of the amyloid ß-protein.
J. Biol. Chem., 268(31):22959-22962, 1993.
[PDF] , PID: 841, PK: 40, Admin
Kamphuis, P.J., and Wurtman, R.J.
Nutrition and Alzheimer's disease: pre-clinical concepts.
European Journal of Neurology, 16 (Supplement 1):12-18, 2009.
[PDF] , PID: 1040, PK: 398, Admin
Lee, R.K.K., Araki, W., and Wurtman, R.J.
Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation.
Proc. Natl. Acad. Sci., 94:5422-5426, 1997.
[PDF] , PID: 936, PK: 49, Admin
Lee, R.K.K., Knapp, S., and Wurtman, R.J.
Prostaglandin E2 stimulates amyloid precursor protein gene expression: Inhibition by immunosuppressants.
J. Neurosci., 19(3):940-947, 1999.
[PDF] , PID: 959, PK: 52, Admin
Lee, R.K.K., Wurtman, R.J., Cox, A.J., and Nitsch, R.M.
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Proc. Natl. Acad. Sci., 92:8083-8087, 1995.
[PDF] , PID: 905, PK: 43, Admin
Lee, R.K.K., and Wurtman, R.J.
Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: Inhibition by cyclic AMP.
J. Neurochem., 68(5):1830-1835, 1997.
[PDF] , PID: 926, PK: 48, Admin
Nitsch, R.M., Blusztajn, J.K., Pittas, A.G., Slack, B.E., Growdon, J.H., Wurtman, R.J.
Evidence for a membrane defect in Alzheimer disease brain.
Proc. Natl. Acad. Sci., 89:1671-1675, 1992.
[PDF] , PID: 837, PK: 38, Admin
Nitsch, R.M., Deng, A., Wurtman, R.J., and Growdon, J.H.
Metabotropic glutamate receptor subtype mGluR1a stimulates the secretion of the amyloid ß-protein precursor ectodomain.
J. Neurochem., 69(2):704-712, 1997.
[PDF] , PID: 941, PK: 50, Admin
Nitsch, R.M., Deng, M., Growdon, J.H., and Wurtman, R.J.
Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.
J. Biol. Chem., 271(8):4188-4194, 1996.
[PDF] , PID: 911, PK: 45, Admin
Nitsch, R.M., Farber, S.A., Growdon, J.H., and Wurtman, R.J.
Release of amyloid ß-protein precursor derivatives by electrical depolarization of rat hippocampal slices.
Proc. Natl. Acad. Sci., 90:5191-5193, 1993.
[PDF] , PID: 861, PK: 41, Admin
Nitsch, R.M., Slack, B.E., Wurtman, R.J., Growdon, J.H.
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
Science, 258:304-307, 1992.
[PDF] , PID: 850, PK: 39, Admin
Nitsch, R.M., Wurtman, R.J., Growdon, J.H.
Regulation of proteolytic processing of the amyloid ß-protein precursor by first messengers: A novel approach for the treatment of Alzheimer's disease.
Drug Res., 45(1):435-438, 1995.
[PDF] , PID: 893, PK: 42, Admin
Petryniak, M.A., Wurtman, R.J., and Slack, B.E.
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism.
Biochem. J., 320:957-963, 1996.
[PDF] , PID: 917, PK: 46, Admin
Pooler, A.M., Arjona, A.A., Lee, R.K., and Wurtman, R.J.
Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia.
Neurosci. Letters, 362:127-130, 2004.
[PDF] , PID: 984, PK: 56, Admin
Pooler, A.M., Xi, S.C., Wurtman, R.J.
The 3-hydrox-3-methyglutary co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.
J. Neurochem., 97:716-723, 2006.
[PDF] , PID: 998, PK: 59, Admin
Scheltens, P., Kamphuis, P.J.G.H., Verhey, F.R.J., olde Rikkert, M.G.M., Wurtman, R.J., Wilkinson, D., Twisk J.W.R., Kurz, A.
Efficacy of a medical food in mild Alzheimer's disease: a randomized controlled trial.
Alzheimer's and Dementia, 6:1-10, 2010.
[PDF] , PID: 1041, PK: 399, Admin
Scheltens, P., Twisk, J.W.R., Blesa, R., Scarpini, E., von Arnim C.A.F., Bongers, A., Harrison, J., Swinkels, S.H.N., Stam, C.J., de Waal, H., Wurtman, R.J., Wieggers, R.L., Vellas, B., Kamphuis, P.J.G.H.
Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial.
Journal of Alzheimer's Disease, 31:225-236, 2012.
[PDF] , PID: 1051, PK: 1126, Admin
Slack, B.E., Breu, J., Muchnicki, L., and Wurtman, R.J.
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: Role of protein kinase C.
Biochem. J., 327:245-249, 1997.
[PDF] , PID: 942, PK: 51, Admin
Slack, B.E., Wurtman, R.J.
Regulation of synthesis and metabolism of the amyloid precursor protein by extracellular signals.
Research Progress in Alzheimer's Disease and Dementia ed. Miao-Kun Sun,Chpt. 1, pp. 1-29, 2006.
[PDF] , PID: 1018, PK: 60, Admin
Teather, L.A. and Wurtman, R.J.
Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats.
Progress in Neuro-Psychopharm. & Biological Psychiatry, 27:711-717, 2003.
[PDF] , PID: 996, PK: 58, Admin
Teather, L.A. and Wurtman, R.J.
Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats.
Learning and Memory, 12:39-43, 2005.
[PDF] , PID: 995, PK: 57, Admin
Teather, L.A., Magnusson, J.E., Chow, C.M., and Wurtman, R.J.
Environmental conditions influence hippocampal-dependent behaviors and brain levels of amyloid precursor protein.
Eur. J. Neurosci., 16:2405-2415, 2002.
[PDF] , PID: 991, PK: 55, Admin
Ulus, I.H., and Wurtman, R.J.
Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.
J. Pharm. Exp. Ther., 281:149-154, 1997.
[PDF] , PID: 925, PK: 47, Admin
Wang, C., Wurtman, R.J., and Lee, R.K.K.
Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Aß1-40.
Brain Res., 865:157-167, 2000.
[PDF] , PID: 966, PK: 53, Admin
Wurtman, R.
Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents.
Metabolism, 57(2):S6-S10, 2008.
[PDF] , PID: 1030, PK: 65, Admin
Wurtman, R.J.
Alzheimer's disease.
Sci. Am., 252:62-74, 1985.
[PDF] , PID: 629, PK: 37, Admin
Wurtman, R.J.
Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses.
Frontiers in Psychiatry, 1/Article 147:1-2, 2010.
[PDF] , PID: 1044, PK: 1097, Admin
Wurtman, R.J.
Involvement of nutrients in the pathogenesis or management of Alzheimer’s disease.
US Neurology, 7(2):, 2011.
[PDF] , PID: 1046, PK: 1115, Admin
Wurtman, R.J.
Non-nutritional uses of nutrients.
European Journal of Pharmacology, 668:S10-S15, 2011.
[PDF] , PID: 1048, PK: 1123, Admin
Wurtman, R.J.
A nutrient combination that can affect synapse formation.
Nutrients, 6, doi:10.3390/nu6041701:1701-1710, 2014.
[PDF] , PID: 1054, PK: 1132, Admin
Wurtman, R.J.
Biomarkers in the diagnosis and management of Alzheimers.
Metabolism, 64:S47-S50, 2014.
[PDF] , PID: 1053, PK: 1134, Admin
Wurtman, R.J.
How anticholinergic drugs might promote Alzheimer's dementia: more A-beta and less phosphatidycholine..
Wurtman, R.J. How anticholinergic drugs might promote Alzheimer's dementia: more A-beta and less phosphatidycholine.. , 46:983-987, 2015.
[PDF] , PID: 1059, PK: 1139, Admin
Wurtman, R.J.
Connectomics and Other Novel Methods for Examining Neural Systems.
Metabolism, 69:S13-S15, 2017.
[PDF] , PID: 1060, PK: 1142, Admin
Wurtman, R.J., Cansev, M., Sakamoto, T., Ulus, I.H.
Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. Omega-3 Fatty Acids, the Brain and Retina.
World Review of Nutrition and Dietetics (A.P. Simopoulos, N.G. Gazan, eds.), Karger, Basel, Vol. 99, pp. S153-S168, 2008.
[PDF] , PID: 1032, PK: 66, Admin
Wurtman, R.J., Cansev, M., Sakamoto, T., Ulus, I.H.
Nutritional modifiers of aging brain function: increasing the formation of brain synapses by administering uridine and other phosphatide precursors.
Nutrition Reviews, 68(Suppl 2):S88-S101, 2010.
[PDF] , PID: 1042, PK: 1095, Admin
Wurtman, R.J., Cansev, M., Sakamoto, T., and Ulus, I.H.
Use of phosphatide precursors to promote synaptogenesis.
Annual Reviews of Nutrition, 29:59-87, 2009.
[PDF] , PID: 1035, PK: 67, Admin
Wurtman, R.J., Cansev, M., Ulus, I.H.
Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides.
The Journal of Nutrition, Health & Aging, 13(3):, 2009.
[PDF] , PID: 1036, PK: 152, Admin
Wurtman, Richard J
Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses.
Frontiers in Psychiatry, 1 Article 147:1-2, None.
[PDF] , PID: 1044, PK: 1145, Admin
Wurtman, Richard J
Synapse formation in the brain can be enhanced by co-administering three specific nutrients.
European Journal of Pharmacology, https://doi.org/10.1016/j.ejph:1-7, 2017.
[PDF] , PID: 1062, PK: 1146, Admin
van Wijk, N., Watkins, C.J., Bohlke, M., Maher, T.J., Hagema, R.J.J, Kamphuis, P.J.G.H., Broersen, L.M., Wurtman, R.J.
Plasma choline concentration varies with different dietary levels of vitamins B6, B12 and folic acid in rats maintained on choline-adequate diets.
British Journal of Nutrition, 107:1408-1412, 2012.
[PDF] , PID: 1045, PK: 1112, Admin
van Wijk, N., Watkins, C.J., Hageman, R.J.J., Sijben, J.W.C., Kamphuis, P.J.G.H., Wurtman, R.J., Broersen, L.M.
Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats.
Nutrition & Metabolism, 9:49 :doi:10.1186/1743-7075-9-49, 2012.
[PDF] , PID: 1052, PK: 1116, Admin