Selected publications on Alzheimer's diseaseAuthors - Title - (Year) - Journal - PDF available - Internal PID - Database PK
Effect of 5-HT2C serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in Guinea pigs.
Brain Research, 951:135-140, 2002.
Giving uridine plus docosahexaenoic acid supplementation orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups.
Developmental Neuroscience, 31:181-192, 2009.
Evidence for the existence of pyrimidinergic transmission in rat brain.
Neuropharmacology, 91:77-86, 2015.
Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease.
Neuroscience Research, 62:206-209, 2008.
Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.
Alzheimer's & Dementia, 4:S153-S168, 2008.
Regulated secretion of ß-amyloid precursor protein in rat brain.
J. Neurosci., 15(11):7442-7451, 1995.
A nutritional approach to ameliorate altered phospholipid metabolism in AD.
A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease.
Journal of Alzheimer's Disease, 41:715-717, 2014.
Activation of protein kinase C inhibits cellular production of the amyloid ß-protein.
J. Biol. Chem., 268(31):22959-22962, 1993.
Nutrition and Alzheimer's disease: pre-clinical concepts.
European Journal of Neurology, 16 (Supplement 1):12-18, 2009.
Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation.
Proc. Natl. Acad. Sci., 94:5422-5426, 1997.
Prostaglandin E2 stimulates amyloid precursor protein gene expression: Inhibition by immunosuppressants.
J. Neurosci., 19(3):940-947, 1999.
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Proc. Natl. Acad. Sci., 92:8083-8087, 1995.
Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: Inhibition by cyclic AMP.
J. Neurochem., 68(5):1830-1835, 1997.
Evidence for a membrane defect in Alzheimer disease brain.
Proc. Natl. Acad. Sci., 89:1671-1675, 1992.
Metabotropic glutamate receptor subtype mGluR1a stimulates the secretion of the amyloid ß-protein precursor ectodomain.
J. Neurochem., 69(2):704-712, 1997.
Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.
J. Biol. Chem., 271(8):4188-4194, 1996.
Release of amyloid ß-protein precursor derivatives by electrical depolarization of rat hippocampal slices.
Proc. Natl. Acad. Sci., 90:5191-5193, 1993.
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
Science, 258:304-307, 1992.
Regulation of proteolytic processing of the amyloid ß-protein precursor by first messengers: A novel approach for the treatment of Alzheimer's disease.
Drug Res., 45(1):435-438, 1995.
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism.
Biochem. J., 320:957-963, 1996.
Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia.
Neurosci. Letters, 362:127-130, 2004.
The 3-hydrox-3-methyglutary co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.
J. Neurochem., 97:716-723, 2006.
Efficacy of a medical food in mild Alzheimer's disease: a randomized controlled trial.
Alzheimer's and Dementia, 6:1-10, 2010.
Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial.
Journal of Alzheimer's Disease, 31:225-236, 2012.
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: Role of protein kinase C.
Biochem. J., 327:245-249, 1997.
Regulation of synthesis and metabolism of the amyloid precursor protein by extracellular signals.
Research Progress in Alzheimer's Disease and Dementia ed. Miao-Kun Sun,Chpt. 1, pp. 1-29, 2006.
Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats.
Progress in Neuro-Psychopharm. & Biological Psychiatry, 27:711-717, 2003.
Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats.
Learning and Memory, 12:39-43, 2005.
Environmental conditions influence hippocampal-dependent behaviors and brain levels of amyloid precursor protein.
Eur. J. Neurosci., 16:2405-2415, 2002.
Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.
J. Pharm. Exp. Ther., 281:149-154, 1997.
Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Aß1-40.
Brain Res., 865:157-167, 2000.
Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents.
Metabolism, 57(2):S6-S10, 2008.
Sci. Am., 252:62-74, 1985.
Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses.
Frontiers in Psychiatry, 1/Article 147:1-2, 2010.
Involvement of nutrients in the pathogenesis or management of Alzheimer’s disease.
US Neurology, 7(2):, 2011.
Non-nutritional uses of nutrients.
European Journal of Pharmacology, 668:S10-S15, 2011.
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.
A nutrient combination that can affect synapse formation.
Nutrients, 6, doi:10.3390/nu6041701:1701-1710, 2014.
Biomarkers in the diagnosis and management of Alzheimers.
Neural systems and connectomics.
How anticholinergic drugs might promote Alzheimer's dementia: more A-beta and less phosphatidycholine..
Wurtman, R.J. How anticholinergic drugs might promote Alzheimer's dementia: more A-beta and less phosphatidycholine.. , 46:983-987, 2015.
Connectomics and Other Novel Methods for Examining Neural Systems.
Metabolism, 69:S13-S15, 2017.
Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. Omega-3 Fatty Acids, the Brain and Retina.
World Review of Nutrition and Dietetics (A.P. Simopoulos, N.G. Gazan, eds.), Karger, Basel, Vol. 99, pp. S153-S168, 2008.
Nutritional modifiers of aging brain function: increasing the formation of brain synapses by administering uridine and other phosphatide precursors.
Nutrition Reviews, 68(Suppl 2):S88-S101, 2010.
Use of phosphatide precursors to promote synaptogenesis.
Annual Reviews of Nutrition, 29:59-87, 2009.
Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides.
The Journal of Nutrition, Health & Aging, 13(3):, 2009.
A nutrient combination that can affect synapse formation.
Plasma choline concentration varies with different dietary levels of vitamins B6, B12 and folic acid in rats maintained on choline-adequate diets.
British Journal of Nutrition, 107:1408-1412, 2012.
Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats.
Nutrition & Metabolism, 9:49 :doi:10.1186/1743-7075-9-49, 2012.